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    GON4L gon-4 like [ Homo sapiens (human) ]

    Gene ID: 54856, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GON4Lprovided by HGNC
    Official Full Name
    gon-4 likeprovided by HGNC
    Primary source
    HGNC:HGNC:25973
    See related
    Ensembl:ENSG00000116580 MIM:610393; AllianceGenome:HGNC:25973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GON4; YARP; GON-4
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within B cell differentiation. Located in nuclear body. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 11.0), spleen (RPKM 8.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GON4L in Genome Data Viewer
    Location:
    1q22
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155745112..155859431, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154888528..154998299, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155719450..155829222, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene YY1 associated protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155657971-155658605 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1818 Neighboring gene uncharacterized LOC124904431 Neighboring gene death associated protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1819 Neighboring gene misato family member 2, pseudogene Neighboring gene small Cajal body-specific RNA 26B Neighboring gene Sharpr-MPRA regulatory region 7686 Neighboring gene proteasome 26S subunit, non-ATPase 7 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155827371-155827958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1822 Neighboring gene synaptotagmin 11 Neighboring gene uncharacterized LOC124904686

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a structural homolog of YY1AP, a coactivator of the multifunctional transcription factor YY1. Ohtomo T, et al. Amino Acids, 2007 Nov. PMID 17297563
    2. GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis. Agarwal N, et al. Cancer Res, 2016 Sep 1. PMID 27312530, Free PMC Article
    3. Cloning and expression analysis of YY1AP-related protein in the rat brain. Ohtomo T, et al. Amino Acids, 2008 Jan. PMID 17285227
    4. Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations. Bucholc K, et al. Int J Mol Sci, 2020 Jul 24. PMID 32722282, Free PMC Article
    5. A conserved interaction that is essential for the biogenesis of histone locus bodies. Yang XC, et al. J Biol Chem, 2014 Dec 5. PMID 25339177, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations.
      Title: Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations.
    2. our results define GON4L as a novel driver of cancer growth
      Title: GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis.
    3. The conserved C-terminal domain shared by FLASH, YARP, and Mute recognizes the C-terminal sequence of NPAT orthologues, thus acting as a signal targeting proteins to histone locus bodies.
      Title: A conserved interaction that is essential for the biogenesis of histone locus bodies.
    4. Sin3a, HDAC1, and YY1 are co-factors for Gon4l and that Gon4l may function as a platform for the assembly of complexes that regulate gene expression.
      Title: The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. study describes the cloning of a novel homolog of YY1AP, referred to as YARP; it is proposed that YARP is multifunctional and plays not only a role analogous to YY1AP, but also its own specific roles in DNA-utilizing processes such as transcription
      Title: Molecular cloning of a structural homolog of YY1AP, a coactivator of the multifunctional transcription factor YY1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12923, FLJ20203, FLJ23040, KIAA1606, MGC138817, MGC138818, DKFZp761I241, RP11-101O6.1, RP11-243J18.4

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GON-4-like protein
    Names
    2610100B20Rik
    YY1AP related protein
    YY1AP-related protein1
    gon-4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282856.2 → NP_001269785.1  GON-4-like protein isoform c

      See identical proteins and their annotated locations for NP_001269785.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 3 and 4 encode the same, longest protein (isoform c).
      Source sequence(s)
      AL139128, AL162734, AY335491, CN391065
      Consensus CDS
      CCDS60296.1
      UniProtKB/Swiss-Prot
      B7ZBL4, Q14C93, Q3T8J8, Q3T8J9, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6
      UniProtKB/TrEMBL
      A4PB67
      Related
      ENSP00000483100.1, ENST00000615926.4
      Conserved Domains (2) summary
      cd12202
      Location:2143 → 2208
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:1648 → 1693
      PAH; Paired amphipathic helix repeat

    2. NM_001282858.2 → NP_001269787.1  GON-4-like protein isoform a

      See identical proteins and their annotated locations for NP_001269787.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. This results in a shorter protein (isoform a), compared to isoform c.
      Source sequence(s)
      AB195687, AL162734, BC064933, BC114629, CN391065
      Consensus CDS
      CCDS44242.1
      UniProtKB/TrEMBL
      A4PB67
      Related
      ENSP00000396117.1, ENST00000437809.5
      Conserved Domains (2) summary
      cd12202
      Location:2142 → 2207
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:1648 → 1693
      PAH; Paired amphipathic helix repeat

    3. NM_001282860.2 → NP_001269789.1  GON-4-like protein isoform c

      See identical proteins and their annotated locations for NP_001269789.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest protein. Variants 3 and 4 encode isoform (c).
      Source sequence(s)
      AL139128, AL162734
      Consensus CDS
      CCDS60296.1
      UniProtKB/Swiss-Prot
      B7ZBL4, Q14C93, Q3T8J8, Q3T8J9, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6
      UniProtKB/TrEMBL
      A4PB67
      Related
      ENSP00000357315.1, ENST00000368331.6
      Conserved Domains (2) summary
      cd12202
      Location:2143 → 2208
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:1648 → 1693
      PAH; Paired amphipathic helix repeat

    4. NM_001282861.2 → NP_001269790.1  GON-4-like protein isoform b

      See identical proteins and their annotated locations for NP_001269790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains a 3' terminal exon that extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AB195687, AI476308, AK022985, AL139128, BC036740, BC115703
      Consensus CDS
      CCDS1121.1
      UniProtKB/TrEMBL
      Q14BN2
      Related
      ENSP00000478593.2, ENST00000622608.2
      Conserved Domains (1) summary
      PHA03247
      Location:1007 → 1436
      PHA03247; large tegument protein UL36; Provisional

    5. NM_032292.6 → NP_115668.4  GON-4-like protein isoform b

      See identical proteins and their annotated locations for NP_115668.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains a 3' terminal exon that extends past a splice site in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AB195688, AI476308, AL139128, BC036740, BC114629
      Consensus CDS
      CCDS1121.1
      UniProtKB/TrEMBL
      Q14BN2
      Related
      ENSP00000354322.5, ENST00000361040.9
      Conserved Domains (1) summary
      PHA03247
      Location:1007 → 1436
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      155745112..155859431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423299.1 → XP_047279255.1  GON-4-like protein isoform X4

    2. XM_006711394.5 → XP_006711457.1  GON-4-like protein isoform X1

      See identical proteins and their annotated locations for XP_006711457.1

      UniProtKB/TrEMBL
      A4PB67
      Conserved Domains (2) summary
      cd12202
      Location:2142 → 2207
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:1648 → 1693
      PAH; Paired amphipathic helix repeat

    3. XM_047423284.1 → XP_047279240.1  GON-4-like protein isoform X2

      UniProtKB/TrEMBL
      A4PB67

    4. XM_047423298.1 → XP_047279254.1  GON-4-like protein isoform X4

    5. XM_006711393.4 → XP_006711456.1  GON-4-like protein isoform X1

      See identical proteins and their annotated locations for XP_006711456.1

      UniProtKB/TrEMBL
      A4PB67
      Conserved Domains (2) summary
      cd12202
      Location:2142 → 2207
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:1648 → 1693
      PAH; Paired amphipathic helix repeat

    6. XM_047423301.1 → XP_047279257.1  GON-4-like protein isoform X5

    7. XM_047423282.1 → XP_047279238.1  GON-4-like protein isoform X2

      UniProtKB/TrEMBL
      A4PB67

    8. XM_047423291.1 → XP_047279247.1  GON-4-like protein isoform X2

      UniProtKB/TrEMBL
      A4PB67

    9. XM_047423297.1 → XP_047279253.1  GON-4-like protein isoform X4

    10. XM_047423264.1 → XP_047279220.1  GON-4-like protein isoform X1

      UniProtKB/TrEMBL
      A4PB67

    11. XM_047423263.1 → XP_047279219.1  GON-4-like protein isoform X1

      UniProtKB/TrEMBL
      A4PB67

    12. XM_047423277.1 → XP_047279233.1  GON-4-like protein isoform X1

      UniProtKB/TrEMBL
      A4PB67

    13. XM_005245284.4 → XP_005245341.1  GON-4-like protein isoform X3

      See identical proteins and their annotated locations for XP_005245341.1

      UniProtKB/TrEMBL
      A4PB67
      Conserved Domains (2) summary
      cd12202
      Location:1970 → 2035
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:1476 → 1521
      PAH; Paired amphipathic helix repeat

    14. XM_047423296.1 → XP_047279252.1  GON-4-like protein isoform X3

      UniProtKB/TrEMBL
      A4PB67

    15. XM_005245286.4 → XP_005245343.1  GON-4-like protein isoform X7

      Conserved Domains (2) summary
      cd12202
      Location:1338 → 1403
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:844 → 889
      PAH; Paired amphipathic helix repeat

    16. XM_047423307.1 → XP_047279263.1  GON-4-like protein isoform X6

      UniProtKB/TrEMBL
      Q14BN2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      154888528..154998299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337228.1 → XP_054193203.1  GON-4-like protein isoform X4

    2. XM_054337221.1 → XP_054193196.1  GON-4-like protein isoform X1

      UniProtKB/TrEMBL
      A4PB67

    3. XM_054337223.1 → XP_054193198.1  GON-4-like protein isoform X2

      UniProtKB/TrEMBL
      A4PB67

    4. XM_054337227.1 → XP_054193202.1  GON-4-like protein isoform X4

    5. XM_054337220.1 → XP_054193195.1  GON-4-like protein isoform X1

      UniProtKB/TrEMBL
      A4PB67

    6. XM_054337229.1 → XP_054193204.1  GON-4-like protein isoform X5

    7. XM_054337222.1 → XP_054193197.1  GON-4-like protein isoform X2

      UniProtKB/TrEMBL
      A4PB67

    8. XM_054337226.1 → XP_054193201.1  GON-4-like protein isoform X4

    9. XM_054337224.1 → XP_054193199.1  GON-4-like protein isoform X3

      UniProtKB/TrEMBL
      A4PB67

    10. XM_054337225.1 → XP_054193200.1  GON-4-like protein isoform X3

      UniProtKB/TrEMBL
      A4PB67

    11. XM_054337231.1 → XP_054193206.1  GON-4-like protein isoform X7

    12. XM_054337230.1 → XP_054193205.1  GON-4-like protein isoform X6

      UniProtKB/TrEMBL
      Q14BN2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037533.1: Suppressed sequence

      Description
      NM_001037533.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    2. NM_025174.1: Suppressed sequence

      Description
      NM_025174.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3T8J9.1 GenPept UniProtKB/Swiss-Prot:Q3T8J9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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