Wdr81 WD repeat domain 81 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr81provided by MGI
Official Full Name: WD repeat domain 81provided by MGI
Primary source: MGI:MGI:2681828
See related: Ensembl:ENSMUSG00000045374 AllianceGenome:MGI:2681828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: nur5; Gm883; mFLJ00182
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and phosphatidylinositol 3-kinase inhibitor activity. Involved in mitochondrion organization. Located in mitochondrion. Is expressed in cerebral cortex. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 and hydrocephalus. Orthologous to human WDR81 (WD repeat domain 81). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 9.0), thymus adult (RPKM 8.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.89 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (75331769..75345544, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (75440943..75454808, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFbeta signaling.
Title: WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling.
This study provided evidence that the nur5 mutant mouse strain, which displays tremor and an abnormal gait, as well as Purkinje cell degeneration and photoreceptor cell loss
Title: WDR81 is necessary for purkinje and photoreceptor cell survival.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol 3-kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol 3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in aggrephagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in aggrephagy	ISO Inferred from Sequence Orthology more info
involved_in aggrephagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in early endosome to late endosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: WD repeat-containing protein 81

Names: shakey 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138950.2 → NP_620400.2 WD repeat-containing protein 81

See identical proteins and their annotated locations for NP_620400.2

Status: VALIDATED

Source sequence(s)

AK160585, AL591496, BC061040, CN721357

Consensus CDS

CCDS48849.1

UniProtKB/Swiss-Prot

G5E8V0, Q3TA90, Q3TUS9, Q5ND34, Q6KAR1

UniProtKB/TrEMBL

K4DI77

Related

ENSMUSP00000134266.2, ENSMUST00000173320.8

Conserved Domains (4) summary

cd06071
Location:349 → 589

Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...

COG2319
Location:1624 → 1932

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1645 → 1688

7WD40; WD40 repeat [structural motif]

cl02567
Location:1634 → 1932

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

75331769..75345544 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532548.5 → XP_006532611.1 WD repeat-containing protein 81 isoform X3

UniProtKB/TrEMBL

K4DI77

Conserved Domains (3) summary

cd06071
Location:349 → 589

Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...

sd00039
Location:1645 → 1688

7WD40; WD40 repeat [structural motif]

cl29593
Location:1634 → 1872

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006532547.5 → XP_006532610.1 WD repeat-containing protein 81 isoform X2

UniProtKB/TrEMBL

K4DI77

Conserved Domains (3) summary

cd06071
Location:349 → 589

Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...

sd00039
Location:1656 → 1699

7WD40; WD40 repeat [structural motif]

cl29593
Location:1645 → 1883

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006532546.5 → XP_006532609.1 WD repeat-containing protein 81 isoform X1

UniProtKB/TrEMBL

K4DI77

Conserved Domains (3) summary

cd06071
Location:349 → 589

Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...

sd00039
Location:1656 → 1699

7WD40; WD40 repeat [structural motif]

cl29593
Location:1645 → 1943

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036156441.1 → XP_036012334.1 WD repeat-containing protein 81 isoform X4

Conserved Domains (1) summary

cd06071
Location:349 → 589

Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
XM_011248816.4 → XP_011247118.1 WD repeat-containing protein 81 isoform X5

Conserved Domains (1) summary

cd06071
Location:349 → 589

Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...