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    Gpaa1 GPI anchor attachment protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 14731, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gpaa1provided by MGI
    Official Full Name
    GPI anchor attachment protein 1provided by MGI
    Primary source
    MGI:MGI:1202392
    See related
    Ensembl:ENSMUSG00000022561 AllianceGenome:MGI:1202392
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mGAA1
    Summary
    Predicted to enable GPI-anchor transamidase activity. Predicted to contribute to GPI anchor binding activity. Predicted to be involved in attachment of GPI anchor to protein and protein-containing complex assembly. Predicted to act upstream of or within GPI anchor biosynthetic process. Predicted to be located in several cellular components, including centrosome; endoplasmic reticulum; and mitochondrion. Predicted to be part of GPI-anchor transamidase complex. Orthologous to human GPAA1 (glycosylphosphatidylinositol anchor attachment 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 99.6), duodenum adult (RPKM 96.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Gpaa1 in Genome Data Viewer
    Location:
    15 D3; 15 35.72 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76215494..76219099)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76331294..76334900)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene sphingomyelin phosphodiesterase 5 Neighboring gene 5-oxoprolinase (ATP-hydrolysing) Neighboring gene STARR-seq mESC enhancer starr_39050 Neighboring gene STARR-positive B cell enhancer ABC_E7384 Neighboring gene exosome component 4 Neighboring gene ribosomal protein S6, pseudogene 1 Neighboring gene cytochrome c-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to GPI anchor binding  
    contributes_to GPI anchor binding  
    enables GPI-anchor transamidase activity PubMed 
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex  
    part_of GPI-anchor transamidase complex  
    part_of GPI-anchor transamidase complex  
    located_in centrosome  
    located_in centrosome  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    glycosylphosphatidylinositol anchor attachment 1 protein
    Names
    GAA1 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010331.2NP_034461.1  glycosylphosphatidylinositol anchor attachment 1 protein

      See identical proteins and their annotated locations for NP_034461.1

      Status: PROVISIONAL

      Source sequence(s)
      AK077518
      Consensus CDS
      CCDS37120.1
      UniProtKB/Swiss-Prot
      Q3TNU9, Q9R1U8, Q9WTK3
      UniProtKB/TrEMBL
      E9PW03
      Related
      ENSMUSP00000023221.7, ENSMUST00000023221.13
      Conserved Domains (1) summary
      pfam04114
      Location:126613
      Gaa1; Gaa1-like, GPI transamidase component

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76215494..76219099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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