Commd5 COMM domain containing 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Commd5provided by MGI
Official Full Name: COMM domain containing 5provided by MGI
Primary source: MGI:MGI:1913648
See related: Ensembl:ENSMUSG00000055041 AllianceGenome:MGI:1913648
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hcarg; D15Ertd81e; 2310065H03Rik
Summary: Predicted to be involved in positive regulation of cell growth; positive regulation of epithelial cell differentiation; and proximal tubule morphogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in cerebellum; cerebral cortex; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human COMMD5 (COMM domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in colon adult (RPKM 18.1), ovary adult (RPKM 16.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 36.28 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (76784141..76786223)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (76899941..76901297)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a suggestive localization of mouse Hcarg based on conservation of linkage between human and mouse is on chromosome 15.
Title: Chromosomal mapping of HCaRG, a novel hypertension-related, calcium-regulated gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI854466 (e-PCR)
- UniSTS:165940

RH126275 (e-PCR)
- UniSTS:162983

Readthrough Zfp7-commd5

Readthrough gene: Zfp7-commd5, Included gene: Zfp7

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in proximal tubule morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COMM domain-containing protein 5

Names: hypertension-related, calcium regulated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417568.1 → NP_001404497.1 COMM domain-containing protein 5

Status: VALIDATED

Source sequence(s)

AC157554

UniProtKB/Swiss-Prot

Q8R395, Q9D6R8

UniProtKB/TrEMBL

A0A0R4J0U7

Related

ENSMUSP00000105416.3, ENSMUST00000109793.3
NM_025536.3 → NP_079812.1 COMM domain-containing protein 5

See identical proteins and their annotated locations for NP_079812.1

Status: VALIDATED

Source sequence(s)

AC157554

Consensus CDS

CCDS27594.1

UniProtKB/Swiss-Prot

Q8R395, Q9D6R8

UniProtKB/TrEMBL

A0A0R4J0U7

Related

ENSMUSP00000069159.6, ENSMUST00000068407.6

Conserved Domains (1) summary

cd04753
Location:115 → 224

Commd5_HCaRG; COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal ...