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    Nrdc nardilysin convertase [ Mus musculus (house mouse) ]

    Gene ID: 230598, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nrdcprovided by MGI
    Official Full Name
    nardilysin convertaseprovided by MGI
    Primary source
    MGI:MGI:1201386
    See related
    Ensembl:ENSMUSG00000053510 AllianceGenome:MGI:1201386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nrd1; NRD-C; 2600011I06Rik
    Summary
    Predicted to enable peptidase activity. Involved in negative regulation of cold-induced thermogenesis; positive regulation of membrane protein ectodomain proteolysis; and regulation of nervous system development. Located in mitochondrion. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and upper jaw. Orthologous to human NRDC (nardilysin convertase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 91.8), CNS E11.5 (RPKM 25.7) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nrdc in Genome Data Viewer
    Location:
    4 C7; 4 50.77 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108857852..108918974)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109000655..109061777)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:108520274-108520575 Neighboring gene thioredoxin domain containing 12 (endoplasmic reticulum) Neighboring gene KTI12 homolog, chromatin associated Neighboring gene RAB3B, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_11058 Neighboring gene RIKEN cDNA 8030443G20 gene Neighboring gene STARR-seq mESC enhancer starr_11059 Neighboring gene STARR-positive B cell enhancer ABC_E520 Neighboring gene STARR-seq mESC enhancer starr_11060 Neighboring gene microRNA 761 Neighboring gene STARR-seq mESC enhancer starr_11061 Neighboring gene STARR-seq mESC enhancer starr_11062 Neighboring gene oxysterol binding protein-like 9 Neighboring gene predicted gene, 32581 Neighboring gene STARR-positive B cell enhancer mm9_chr4:108777798-108778099 Neighboring gene STARR-positive B cell enhancer ABC_E521 Neighboring gene STARR-positive B cell enhancer ABC_E6198 Neighboring gene STARR-seq mESC enhancer starr_11065 Neighboring gene predicted gene, 52703

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC25477

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nardilysin
    Names
    N-arginine dibasic convertase
    NRD convertase
    nardilysin, N-arginine dibasic convertase, NRD convertase 1
    NP_001333483.1
    NP_001334098.1
    NP_666262.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346554.1NP_001333483.1  nardilysin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627406, BE949999
      Consensus CDS
      CCDS89800.1
      UniProtKB/TrEMBL
      A6PWC3, Q8R320
      Related
      ENSMUSP00000099797.3, ENSMUST00000102736.9
    2. NM_001347169.2NP_001334098.1  nardilysin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL627406, BE949999
      Consensus CDS
      CCDS84773.1
      UniProtKB/TrEMBL
      A2A9Q2, Q8R320
      Related
      ENSMUSP00000102255.3, ENSMUST00000106644.9
    3. NM_146150.3NP_666262.2  nardilysin isoform 2 precursor

      See identical proteins and their annotated locations for NP_666262.2

      Status: VALIDATED

      Source sequence(s)
      AK031548, BY732391, CF168810
      Consensus CDS
      CCDS18460.1
      UniProtKB/Swiss-Prot
      Q8BHG1
      UniProtKB/TrEMBL
      Q8R320
      Related
      ENSMUSP00000068328.5, ENSMUST00000065977.11
      Conserved Domains (4) summary
      COG1025
      Location:2221100
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:210348
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:373559
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:564845
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      108857852..108918974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)