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    Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a [ Mus musculus (house mouse) ]

    Gene ID: 27279, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnfrsf12aprovided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 12aprovided by MGI
    Primary source
    MGI:MGI:1351484
    See related
    Ensembl:ENSMUSG00000023905 AllianceGenome:MGI:1351484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fn14; HPIP; TweakR; TWEAK-R
    Summary
    Involved in regulation of angiogenesis. Acts upstream of or within extrinsic apoptotic signaling pathway; positive regulation of axon extension; and substrate-dependent cell migration, cell attachment to substrate. Located in cell surface; plasma membrane; and ruffle. Is expressed in several structures, including adrenal medulla; alimentary system; genitourinary system; heart; and limb long bone. Orthologous to human TNFRSF12A (TNF receptor superfamily member 12A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 44.7), ovary adult (RPKM 38.8) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Tnfrsf12a in Genome Data Viewer
    Location:
    17 A3.3; 17 11.99 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23894419..23896423, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23675445..23677449, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 25 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene BICD family like cargo adaptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E8656 Neighboring gene THO complex 6 Neighboring gene host cell factor C1 regulator 1 (XPO1-dependent) Neighboring gene claudin 6 Neighboring gene claudin 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cell surface PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in ruffle PubMed 

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 12A
    Names
    FGF-inducible 14
    fibroblast growth factor-inducible immediate-early response protein 14
    fibroblast growth factor-regulated protein 2
    tweak-receptor
    type I transmembrane protein Fn14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161746.1NP_001155218.1  tumor necrosis factor receptor superfamily member 12A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI853177, AK160136, DV655788
      Consensus CDS
      CCDS50011.1
      UniProtKB/TrEMBL
      E9PZT5
      Related
      ENSMUSP00000131574.2, ENSMUST00000167059.9
      Conserved Domains (1) summary
      cl22855
      Location:194
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    2. NM_013749.2NP_038777.2  tumor necrosis factor receptor superfamily member 12A isoform 1 precursor

      See identical proteins and their annotated locations for NP_038777.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI853177, AK160136
      Consensus CDS
      CCDS28456.1
      UniProtKB/Swiss-Prot
      Q3TVG8, Q9CR75, Q9QZW3
      Related
      ENSMUSP00000024698.9, ENSMUST00000024698.10
      Conserved Domains (2) summary
      cd13413
      Location:933
      TNFRSF12A; CRD1 [structural motif]
      cl22855
      Location:1129
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      23894419..23896423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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