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    Mybpc3 myosin binding protein C3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295929, updated on 3-Dec-2024

    Summary

    Official Symbol
    Mybpc3provided by RGD
    Official Full Name
    myosin binding protein C3provided by RGD
    Primary source
    RGD:1305950
    See related
    EnsemblRapid:ENSRNOG00000012307 AllianceGenome:RGD:1305950
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and myosin heavy chain binding activity. Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction and regulation of striated muscle contraction. Located in striated muscle myosin thick filament. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1MM; familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 4. Orthologous to human MYBPC3 (myosin binding protein C3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 5513.3) See more
    Orthologs
    NEW
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    Genomic context

    See Mybpc3 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97550974..97569216)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77095165..77113406)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (79940509..79958731)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486120 Neighboring gene uncharacterized LOC120101909 Neighboring gene Spi-1 proto-oncogene Neighboring gene MAP-kinase activating death domain Neighboring gene transfer RNA alanine (anticodon AGC) 34 Neighboring gene nuclear receptor subfamily 1, group H, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables myosin heavy chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of muscle IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myosin filament assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of striated muscle contraction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in A band IEA
    Inferred from Electronic Annotation
    more info
     
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cardiac myofibril IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cardiac myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcomere ISO
    Inferred from Sequence Orthology
    more info
     
    located_in striated muscle myosin thick filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in striated muscle myosin thick filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in striated muscle myosin thick filament ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myosin-binding protein C, cardiac-type
    Names
    cardiac MyBP-C
    myosin binding protein C, cardiac

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106490.1NP_001099960.1  myosin-binding protein C, cardiac-type

      See identical proteins and their annotated locations for NP_001099960.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/Swiss-Prot
      P56741
      UniProtKB/TrEMBL
      A0A8I5ZRN0
      Related
      ENSRNOP00000016652.8, ENSRNOT00000016652.8
      Conserved Domains (8) summary
      cd05748
      Location:9901062
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd05894
      Location:656768
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:11951257
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:9811062
      IG_like; Immunoglobulin like
      cd00063
      Location:772862
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:11811270
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:165249
      ig; Immunoglobulin domain
      cl11960
      Location:4092
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      97550974..97569216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283293.1XP_063139363.1  myosin-binding protein C, cardiac-type isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRN0, A0A8L2Q868
      Related
      ENSRNOP00000099748.1, ENSRNOT00000159695.1