Ckmt2 creatine kinase, mitochondrial 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ckmt2provided by RGD
Official Full Name: creatine kinase, mitochondrial 2provided by RGD
Primary source: RGD:61977
See related: EnsemblRapid:ENSRNOG00000055450 AllianceGenome:RGD:61977
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: S-MtCK; mib-CK
Summary: Enables cardiolipin binding activity. Involved in heart development and skeletal muscle tissue development. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human CKMT2 (creatine kinase, mitochondrial 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 7316.4) and Muscle (RPKM 5199.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (24815008..24845511, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (23079918..23110518, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (21422680..21452797, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ckmt2 (e-PCR), detects polymorphism
- UniSTS:499080

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cardiolipin binding	IDA Inferred from Direct Assay more info	PubMed
enables creatine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables creatine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in phosphocreatine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphocreatine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: creatine kinase S-type, mitochondrial

Names: basic-type mitochondrial creatine kinase; creatine kinase, mitochondrial 2, sarcomeric; sarcomeric mitochondrial creatine kinase

NP_001121124.1

EC 2.7.3.2

XP_063138643.1

EC 2.7.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127652.2 → NP_001121124.1 creatine kinase S-type, mitochondrial precursor

See identical proteins and their annotated locations for NP_001121124.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P09605

UniProtKB/TrEMBL

A0A0G2JVQ1, B0BNC0

Related

ENSRNOP00000089864.2, ENSRNOT00000118630.2

Conserved Domains (1) summary

cd00716
Location:50 → 407

creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes