U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sppl2a signal peptide peptidase-like 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311401, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sppl2aprovided by RGD
    Official Full Name
    signal peptide peptidase-like 2Aprovided by RGD
    Primary source
    RGD:1563001
    See related
    EnsemblRapid:ENSRNOG00000011652 AllianceGenome:RGD:1563001
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563001
    Summary
    Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to be located in late endosome membrane and plasma membrane. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SPPL2A (signal peptide peptidase like 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 240.4), Lung (RPKM 216.7) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sppl2a in Genome Data Viewer
    Location:
    3q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134602684..134646752, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (114149337..114193408, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119361651..119405453, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 50 Neighboring gene transient receptor potential cation channel, subfamily M, member 7 Neighboring gene uncharacterized LOC134486145 Neighboring gene mitochondrial fission regulator 1-like Neighboring gene adaptor related protein complex 4 subunit epsilon 1 Neighboring gene uncharacterized LOC134486146 Neighboring gene biliverdin reductase A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Fluhrer R, et al. Nat Cell Biol, 2006 Aug. PMID 16829951
    2. The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. Kirkin V, et al. Cell Death Differ, 2007 Sep. PMID 17557115
    3. In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy. Petroff OA, et al. J Neurochem, 1990 Apr. PMID 2313285
    4. Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail. Behnke J, et al. FEBS Lett, 2011 Oct 3. PMID 21896273
    5. SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. Friedmann E, et al. Nat Cell Biol, 2006 Aug. PMID 16829952

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein intracellular domain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane protein proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi-associated vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lumenal side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    signal peptide peptidase-like 2A
    NP_001101240.1
    XP_006234982.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107770.1 → NP_001101240.1  signal peptide peptidase-like 2A precursor

      See identical proteins and their annotated locations for NP_001101240.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A6HPZ6, D3ZNG3
      Related
      ENSRNOP00000015568.6, ENSRNOT00000015568.8
      Conserved Domains (2) summary
      pfam04258
      Location:214 → 499
      Peptidase_A22B; Signal peptide peptidase
      cl10459
      Location:44 → 163
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      134602684..134646752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234920.5 → XP_006234982.1  signal peptide peptidase-like 2A isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA3
      Related
      ENSRNOP00000070578.2, ENSRNOT00000090355.3
      Conserved Domains (2) summary
      pfam04258
      Location:214 → 517
      Peptidase_A22B; Signal peptide peptidase
      cl10459
      Location:44 → 163
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous