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    Get1 guided entry of tail-anchored proteins factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288233, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Get1provided by RGD
    Official Full Name
    guided entry of tail-anchored proteins factor 1provided by RGD
    Primary source
    RGD:735104
    See related
    EnsemblRapid:ENSRNOG00000001629 AllianceGenome:RGD:735104
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wrb
    Summary
    Predicted to enable protein-membrane adaptor activity. Involved in tail-anchored membrane protein insertion into ER membrane. Part of GET complex. Orthologous to human GET1 (guided entry of tail-anchored proteins factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 175.2), Heart (RPKM 142.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Get1 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (48915298..48929235)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (35438555..35460156)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (36497513..36511445)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL43-like Neighboring gene high mobility group nucleosome binding domain 1 Neighboring gene lebercilin LCA5 like Neighboring gene SH3 domain binding glutamate-rich protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells. Yamamoto Y, et al. Mol Cell, 2012 Nov 9. PMID 23041287
    2. Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. Vogl C, et al. EMBO J, 2016 Dec 1. PMID 27458190, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within otic vesicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tail-anchored membrane protein insertion into ER membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of GET complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GET complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of GET complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guided entry of tail-anchored proteins factor 1
    Names
    tail-anchored protein insertion receptor WRB
    tryptophan rich basic protein
    tryptophan-rich protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199373.1 → NP_955405.1  guided entry of tail-anchored proteins factor 1

      See identical proteins and their annotated locations for NP_955405.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062049
      UniProtKB/Swiss-Prot
      Q6P6S5
      UniProtKB/TrEMBL
      A6KPR9, A6KPS0
      Related
      ENSRNOP00000002222.3, ENSRNOT00000002222.7
      Conserved Domains (1) summary
      pfam04420
      Location:17 → 163
      CHD5; CHD5-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      48915298..48929235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088205.2 → XP_038944133.1  guided entry of tail-anchored proteins factor 1 isoform X1

      UniProtKB/TrEMBL
      A6KPS1
      Conserved Domains (1) summary
      pfam04420
      Location:1 → 115
      CHD5; CHD5-like protein

    2. XM_039088204.2 → XP_038944132.1  guided entry of tail-anchored proteins factor 1 isoform X1

      UniProtKB/TrEMBL
      A6KPS1
      Conserved Domains (1) summary
      pfam04420
      Location:1 → 115
      CHD5; CHD5-like protein

    3. XM_039088208.2 → XP_038944136.1  guided entry of tail-anchored proteins factor 1 isoform X1

      UniProtKB/TrEMBL
      A6KPS1
      Conserved Domains (1) summary
      pfam04420
      Location:1 → 115
      CHD5; CHD5-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6S5.1 GenPept UniProtKB/Swiss-Prot:Q6P6S5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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