Rilpl1 Rab interacting lysosomal protein-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rilpl1provided by RGD
Official Full Name: Rab interacting lysosomal protein-like 1provided by RGD
Primary source: RGD:1307973
See related: EnsemblRapid:ENSRNOG00000001055 AllianceGenome:RGD:1307973
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GOSPEL; RGD1307973
Summary: Predicted to enable dynein light intermediate chain binding activity and small GTPase binding activity. Involved in nitric oxide mediated signal transduction. Located in cytosol. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 4. Orthologous to human RILPL1 (Rab interacting lysosomal protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 462.3), Muscle (RPKM 314.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q15

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (37732847..37770659)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (32071870..32109687)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (37490320..37528393)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Rat36 (e-PCR)
- UniSTS:118284

BE108813 (e-PCR)
- UniSTS:247899

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in nitric oxide mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport from ciliary membrane to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein transport from ciliary membrane to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein transport from ciliary membrane to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RILP-like protein 1

Names: GAPDH's competitor of SIAH1 protein enhances life; rab-interacting lysosomal-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191665.1 → NP_001178594.1 RILP-like protein 1

See identical proteins and their annotated locations for NP_001178594.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

D3ZUQ0

UniProtKB/TrEMBL

A0A8L2PZW4

Related

ENSRNOP00000087559.2, ENSRNOT00000099078.2

Conserved Domains (3) summary

TIGR02169
Location:76 → 322

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam09744
Location:27 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

37732847..37770659

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249296.5 → XP_006249358.1 RILP-like protein 1 isoform X5

UniProtKB/TrEMBL

A0A8I5ZUH1

Conserved Domains (2) summary

pfam09744
Location:28 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein
XM_006249294.3 → XP_006249356.1 RILP-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006249356.1

UniProtKB/TrEMBL

A0A8L2PZW4, A6J0Z1

Related

ENSRNOP00000001401.7, ENSRNOT00000001401.9

Conserved Domains (2) summary

pfam09744
Location:28 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein
XM_006249295.4 → XP_006249357.1 RILP-like protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I5ZUH1

Related

ENSRNOP00000082699.2, ENSRNOT00000115532.2

Conserved Domains (2) summary

pfam09744
Location:28 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein
XM_039089435.2 → XP_038945363.1 RILP-like protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZUH1

Conserved Domains (3) summary

TIGR02169
Location:76 → 322

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam09744
Location:27 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein
XM_039089436.2 → XP_038945364.1 RILP-like protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZUH1

Conserved Domains (3) summary

TIGR02169
Location:76 → 322

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam09744
Location:27 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein
XM_039089439.2 → XP_038945367.1 RILP-like protein 1 isoform X8

UniProtKB/TrEMBL

A0A8I5ZUH1

Conserved Domains (3) summary

TIGR02169
Location:76 → 322

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam09744
Location:27 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein
XM_039089437.2 → XP_038945365.1 RILP-like protein 1 isoform X6

UniProtKB/TrEMBL

A0A0G2K2U5, A0A8I5ZUH1

Conserved Domains (3) summary

TIGR02169
Location:76 → 322

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam09744
Location:27 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein
XM_039089438.2 → XP_038945366.1 RILP-like protein 1 isoform X7

UniProtKB/TrEMBL

A0A8I5ZUH1

Related

ENSRNOP00000072380.3, ENSRNOT00000090831.3

Conserved Domains (3) summary

TIGR02169
Location:76 → 322

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam09744
Location:27 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein