Hexim1 HEXIM P-TEFb complex subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hexim1provided by RGD
Official Full Name: HEXIM P-TEFb complex subunit 1provided by RGD
Primary source: RGD:1559851
See related: EnsemblRapid:ENSRNOG00000003203 AllianceGenome:RGD:1559851
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Clp1; Clp-1
Summary: Predicted to enable several functions, including 7SK snRNA binding activity; P-TEFb complex binding activity; and cyclin-dependent protein serine/threonine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of DNA-templated transcription; negative regulation of viral transcription; and positive regulation of signal transduction by p53 class mediator. Predicted to act upstream of or within heart development and negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of 7SK snRNP. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human HEXIM1 (HEXIM P-TEFb complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (88562889..88565001)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (88062808..88064920)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (91200874..91202986)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 7SK snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables 7SK snRNA binding	ISO Inferred from Sequence Orthology more info
enables 7SK snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables P-TEFb complex binding	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables snRNA binding	ISO Inferred from Sequence Orthology more info
enables snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription regulator inhibitor activity	ISO Inferred from Sequence Orthology more info
enables transcription regulator inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription elongation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of 7SK snRNP	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein HEXIM1

Names: cardiac lineage protein 1; hexamethylene bis-acetamide inducible 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.