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    Usp32 ubiquitin specific peptidase 32 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303394, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usp32provided by RGD
    Official Full Name
    ubiquitin specific peptidase 32provided by RGD
    Primary source
    RGD:1306657
    See related
    EnsemblRapid:ENSRNOG00000027711 AllianceGenome:RGD:1306657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in positive regulation of TORC1 signaling. Predicted to be located in cytosol. Predicted to be active in Golgi apparatus. Orthologous to human USP32 (ubiquitin specific peptidase 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 221.0), Adrenal (RPKM 211.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Usp32 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70353310..70538008, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69855895..70029075, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72300173..72474574, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37A, pseudogene 3 Neighboring gene carbonic anhydrase 4 Neighboring gene DAB adaptor protein 1, pseudogene 1 Neighboring gene tetra-peptide repeat homeobox-like protein Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene CHD1 helical C-terminal domain containing 1 Neighboring gene amyloid beta precursor protein binding protein 2 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers. Akhavantabasi S, et al. Mamm Genome, 2010 Aug. PMID 20549504
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 32
    Names
    ubiquitin specific protease 32
    NP_001388596.1
    XP_017452797.1
    XP_038941969.1
    XP_038941970.1
    XP_063125160.1
    XP_063125161.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401667.1 → NP_001388596.1  ubiquitin carboxyl-terminal hydrolase 32

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A5X2
      Related
      ENSRNOP00000111074.1, ENSRNOT00000170376.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      70353310..70538008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597308.3 → XP_017452797.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5X2
      Related
      ENSRNOP00000074862.3, ENSRNOT00000081649.3

    2. XM_039086041.2 → XP_038941969.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5X2
      Conserved Domains (3) summary
      COG5126
      Location:254 → 404
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      COG5560
      Location:583 → 1395
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam00443
      Location:1314 → 1643
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. XM_063269091.1 → XP_063125161.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A5X2
      Related
      ENSRNOP00000031281.4, ENSRNOT00000036814.7

    4. XM_039086042.2 → XP_038941970.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A5X2
      Related
      ENSRNOP00000088848.1, ENSRNOT00000111648.2
      Conserved Domains (3) summary
      COG5126
      Location:189 → 339
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      COG5560
      Location:518 → 1330
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam00443
      Location:1249 → 1578
      UCH; Ubiquitin carboxyl-terminal hydrolase

    5. XM_063269090.1 → XP_063125160.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A5X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107032.1: Suppressed sequence

      Description
      NM_001107032.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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