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    Pacsin3 protein kinase C and casein kinase substrate in neurons 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311187, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pacsin3provided by RGD
    Official Full Name
    protein kinase C and casein kinase substrate in neurons 3provided by RGD
    Primary source
    RGD:1307327
    See related
    EnsemblRapid:ENSRNOG00000014204 AllianceGenome:RGD:1307327
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SdpIII
    Summary
    Predicted to enable several functions, including calcium channel inhibitor activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including negative regulation of calcium ion transport; plasma membrane tubulation; and positive regulation of membrane protein ectodomain proteolysis. Predicted to act upstream of or within negative regulation of endocytosis. Predicted to be located in cytosol. Predicted to be active in endosome and plasma membrane. Orthologous to human PACSIN3 (protein kinase C and casein kinase substrate in neurons 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 626.4), Heart (RPKM 232.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pacsin3 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97683054..97691619)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77227187..77235820)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80072425..80081058)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene damage specific DNA binding protein 2 Neighboring gene ARF GTPase activating protein 2 Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene uncharacterized LOC120101910

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interleukin-6 affects pacsin3, ephrinA4 expression and cytoskeletal proteins in differentiating primary skeletal myoblasts through transcriptional and post-transcriptional mechanisms. Milewska M, et al. Cell Tissue Res, 2020 Apr. PMID 31820147
    2. Versatile membrane deformation potential of activated pacsin. Goh SL, et al. PLoS One, 2012. PMID 23236520, Free PMC Article
    3. Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules. Bai X, et al. J Biol Chem, 2012 Jun 22. PMID 22573331, Free PMC Article
    4. Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. D'hoedt D, et al. J Biol Chem, 2008 Mar 7. PMID 18174177
    5. PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. Cuajungco MP, et al. J Biol Chem, 2006 Jul 7. PMID 16627472

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interleukin-6 affects pacsin3, ephrinA4 expression and cytoskeletal proteins in differentiating primary skeletal myoblasts through transcriptional and post-transcriptional mechanisms.
      Title: Interleukin-6 affects pacsin3, ephrinA4 expression and cytoskeletal proteins in differentiating primary skeletal myoblasts through transcriptional and post-transcriptional mechanisms.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase C and casein kinase substrate in neurons protein 3
    Names
    protein kinase C and casein kinase II substrate protein 3
    syndapin III

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009966.3 → NP_001009966.2  protein kinase C and casein kinase substrate in neurons protein 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNC1, G3V9N7, Q5I2Z0
      Related
      ENSRNOP00000054003.5, ENSRNOT00000057176.6
      Conserved Domains (2) summary
      cd11997
      Location:365 → 420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16 → 273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      97683054..97691619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283658.1 → XP_063139728.1  protein kinase C and casein kinase substrate in neurons protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXX4, Q5I2Z0
      Related
      ENSRNOP00000070437.2, ENSRNOT00000080266.3

    2. XM_063283659.1 → XP_063139729.1  protein kinase C and casein kinase substrate in neurons protein 3 isoform X2

      UniProtKB/TrEMBL
      Q5I2Z0
      Related
      ENSRNOP00000099585.1, ENSRNOT00000157559.1

    3. XM_063283660.1 → XP_063139730.1  protein kinase C and casein kinase substrate in neurons protein 3 isoform X3

      UniProtKB/TrEMBL
      A6HNC1, G3V9N7, Q5I2Z0
    Nucleotide Protein Strain
    Heading Accession and Version

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