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    Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81678, updated on 9-Dec-2024

    Summary

    Symbol
    Itpr2provided by RGD
    Full Name
    inositol 1,4,5-trisphosphate receptor, type 2provided by RGD
    Primary source
    RGD:69649
    See related
    EnsemblRapid:ENSRNOG00000001804 AllianceGenome:RGD:69649
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium ion binding activity; inositol 1,4,5 trisphosphate binding activity; and inositol 1,4,5-trisphosphate-gated calcium channel activity. Involved in cellular response to hypoxia and release of sequestered calcium ion into cytosol. Located in axon; endoplasmic reticulum membrane; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 267.0), Kidney (RPKM 144.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Itpr2 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    62
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (180759325..181165361, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179028594..179434657, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (180423452..180800088, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix family, member e41 Neighboring gene uncharacterized LOC102549898 Neighboring gene sarcospan Neighboring gene uncharacterized LOC134486658 Neighboring gene uncharacterized LOC134486659 Neighboring gene E3 SUMO-protein ligase NSE2-like Neighboring gene integrator complex subunit 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol 1,4,5 trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol 1,4,5 trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol 1,4,5 trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables inositol 1,4,5-trisphosphate-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables intracellularly gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sarcoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in secretory granule membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inositol 1,4,5-trisphosphate-gated calcium channel ITPR2; inositol 1,4,5-trisphosphate receptor type 2
    Names
    IP3 receptor
    IP3R 2
    inositol 1,4,5-triphosphate receptor 2
    inositol 1,4,5-triphosphate receptor, type 2
    inositol triphosphate receptor type 2
    insP3R2
    type 2 InsP3 receptor
    type 2 inositol 1,4,5-trisphosphate receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031046.4NP_112308.2  inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      Q6W3E4
      Related
      ENSRNOP00000077641.1, ENSRNOT00000103103.2
      Conserved Domains (5) summary
      pfam00520
      Location:22902552
      Ion_trans; Ion transport protein
      pfam01365
      Location:473670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232432
      MIR; MIR domain
      pfam08454
      Location:19152022
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4228
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      180759325..181165361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108425.1XP_038964353.1  inositol 1,4,5-trisphosphate receptor type 2 isoform X1

      UniProtKB/TrEMBL
      Q6W3E4
      Conserved Domains (5) summary
      pfam00520
      Location:23402603
      Ion_trans; Ion transport protein
      pfam01365
      Location:523720
      RYDR_ITPR; RIH domain
      pfam02815
      Location:282482
      MIR; MIR domain
      pfam08454
      Location:19652072
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:82278
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    2. XM_063286748.1XP_063142818.1  inositol 1,4,5-trisphosphate receptor type 2 isoform X1

      UniProtKB/TrEMBL
      Q6W3E4
    3. XM_039108427.2XP_038964355.1  inositol 1,4,5-trisphosphate receptor type 2 isoform X2

      UniProtKB/TrEMBL
      Q6W3E4
      Related
      ENSRNOP00000101675.1, ENSRNOT00000173337.1
      Conserved Domains (5) summary
      pfam00520
      Location:23402602
      Ion_trans; Ion transport protein
      pfam01365
      Location:523720
      RYDR_ITPR; RIH domain
      pfam02815
      Location:282482
      MIR; MIR domain
      pfam08454
      Location:19652072
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:82278
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    4. XM_039108429.2XP_038964357.1  inositol 1,4,5-trisphosphate receptor type 2 isoform X4

      UniProtKB/TrEMBL
      Q6W3E4
      Conserved Domains (5) summary
      pfam00520
      Location:22282491
      Ion_trans; Ion transport protein
      pfam01365
      Location:411608
      RYDR_ITPR; RIH domain
      pfam02815
      Location:170370
      MIR; MIR domain
      pfam08454
      Location:18531960
      RIH_assoc; RyR and IP3R Homology associated
      cl19745
      Location:1166
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    5. XM_039108430.2XP_038964358.1  inositol 1,4,5-trisphosphate receptor type 2 isoform X4

      UniProtKB/TrEMBL
      Q6W3E4
      Conserved Domains (5) summary
      pfam00520
      Location:22282491
      Ion_trans; Ion transport protein
      pfam01365
      Location:411608
      RYDR_ITPR; RIH domain
      pfam02815
      Location:170370
      MIR; MIR domain
      pfam08454
      Location:18531960
      RIH_assoc; RyR and IP3R Homology associated
      cl19745
      Location:1166
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    6. XM_039108428.2XP_038964356.1  inositol 1,4,5-trisphosphate receptor type 2 isoform X3

      UniProtKB/TrEMBL
      F1LNT1, Q6W3E4
      Related
      ENSRNOP00000043615.5, ENSRNOT00000040255.7
      Conserved Domains (5) summary
      pfam00520
      Location:22902553
      Ion_trans; Ion transport protein
      pfam01365
      Location:473670
      RYDR_ITPR; RIH domain
      pfam02815
      Location:232432
      MIR; MIR domain
      pfam08454
      Location:19152022
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:4228
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor