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    Acot12 acyl-CoA thioesterase 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170570, updated on 3-Dec-2024

    Summary

    Official Symbol
    Acot12provided by RGD
    Official Full Name
    acyl-CoA thioesterase 12provided by RGD
    Primary source
    RGD:619752
    See related
    EnsemblRapid:ENSRNOG00000061414 AllianceGenome:RGD:619752
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cach; rACH
    Summary
    Enables acetyl-CoA hydrolase activity and identical protein binding activity. Involved in acyl-CoA metabolic process. Located in cytosol. Used to study liver cancer. Orthologous to human ACOT12 (acyl-CoA thioesterase 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 345.8) and Kidney (RPKM 71.1) See more
    Orthologs
    NEW
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    Genomic context

    See Acot12 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (24721648..24763686)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (22986867..23027538)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (20857056..20901656)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene single-stranded DNA binding protein 2 Neighboring gene transfer RNA leucine (anticodon AAG) 15 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120100551 Neighboring gene zinc finger CCHC-type containing 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables acetyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in acetyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within acetyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acetyl-coenzyme A thioesterase
    Names
    CACH-1
    acyl-CoA thioester hydrolase 12
    acyl-coenzyme A thioesterase 12
    cytoplasmic acetyl-CoA hydrolase 1
    cytosolic acetyl-CoA hydrolase
    rCACH-1
    NP_570103.1
    XP_063137283.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130747.1NP_570103.1  acetyl-coenzyme A thioesterase

      See identical proteins and their annotated locations for NP_570103.1

      Status: PROVISIONAL

      Source sequence(s)
      AB040609
      UniProtKB/Swiss-Prot
      Q99NB7
      UniProtKB/TrEMBL
      A6I4P8
      Related
      ENSRNOP00000075534.1, ENSRNOT00000078919.3
      Conserved Domains (2) summary
      cd03442
      Location:178296
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
      cl14643
      Location:312547
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      24721648..24763686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281213.1XP_063137283.1  acetyl-coenzyme A thioesterase isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAU8