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    Myh7 myosin heavy chain 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29557, updated on 3-Dec-2024

    Summary

    Official Symbol
    Myh7provided by RGD
    Official Full Name
    myosin heavy chain 7provided by RGD
    Primary source
    RGD:62030
    See related
    EnsemblRapid:ENSRNOG00000016983 AllianceGenome:RGD:62030
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bmyo; Myhcb; myHC-beta; myHC-slow
    Summary
    Enables several functions, including ATP binding activity; ATP hydrolysis activity; and identical protein binding activity. Involved in several processes, including cellular response to 3,3',5-triiodo-L-thyronine; cellular response to angiotensin; and cellular response to hydrogen peroxide. Located in myosin filament and sarcomere. Part of muscle myosin complex. Biomarker of congestive heart failure; hypertension; hypothyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (myosin heavy chain 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 18484.9) and Muscle (RPKM 5773.0) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Myh7 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32416525..32439851, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28446550..28469888, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33605769..33657761, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene CKLF-like MARVEL transmembrane domain containing 5 Neighboring gene uncharacterized LOC108352923 Neighboring gene myosin heavy chain 6 Neighboring gene microRNA 3546 Neighboring gene microRNA 208a Neighboring gene uncharacterized LOC120096985 Neighboring gene uncharacterized LOC120096984 Neighboring gene microRNA 208b Neighboring gene neuroguidin Neighboring gene uncharacterized LOC134482119

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microfilament motor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adult heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adult heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adult heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle hypertrophy in response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to 3,3',5-triiodo-L-thyronine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to angiotensin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle filament sliding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle filament sliding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle filament sliding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of slow-twitch skeletal muscle fiber contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of slow-twitch skeletal muscle fiber contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of the force of heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of the force of skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of the force of skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transition between fast and slow fiber IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within transition between fast and slow fiber ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of muscle myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of myosin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in myosin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myosin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myosin-7
    Names
    beta myosin heavy chain
    myosin heavy chain polypeptide 7 cardiac muscle fetal
    myosin heavy chain, cardiac muscle, fetal
    myosin heavy chain, polypeptide 7
    myosin, heavy chain 7, cardiac muscle, beta
    myosin, heavy polypeptide 7, cardiac muscle, beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017240.2NP_058936.1  myosin-7

      See identical proteins and their annotated locations for NP_058936.1

      Status: PROVISIONAL

      Source sequence(s)
      X15939
      UniProtKB/Swiss-Prot
      P02563, P02564, Q63351
      Related
      ENSRNOP00000024186.3, ENSRNOT00000024186.5
      Conserved Domains (7) summary
      cd01377
      Location:99766
      MYSc_class_II; class II myosins, motor domain
      pfam00063
      Location:87766
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8461923
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3572
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:17401830
      TMPIT; TMPIT-like protein
      cl00817
      Location:11321293
      MM_CoA_mutase; Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of ...
      cl12013
      Location:12321424
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32416525..32439851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251951.4XP_006252013.1  myosin-7 isoform X1

      See identical proteins and their annotated locations for XP_006252013.1

      UniProtKB/Swiss-Prot
      P02563, Q63351
      UniProtKB/TrEMBL
      A6KGY1, G3V8B0
      Conserved Domains (7) summary
      cd01377
      Location:99766
      MYSc_class_II; class II myosins, motor domain
      pfam00063
      Location:87766
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8461923
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3572
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:17401830
      TMPIT; TMPIT-like protein
      cl00817
      Location:11321293
      MM_CoA_mutase; Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of ...
      cl12013
      Location:12321424
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_063274187.1XP_063130257.1  myosin-7 isoform X1

      UniProtKB/Swiss-Prot
      P02563, Q63351
      UniProtKB/TrEMBL
      A6KGY1, G3V8B0