RBM24 RNA binding motif protein 24 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RBM24provided by HGNC
Official Full Name: RNA binding motif protein 24provided by HGNC
Primary source: HGNC:HGNC:21539
See related: Ensembl:ENSG00000112183 MIM:617603; AllianceGenome:HGNC:21539
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RNPC6; dJ259A10.1
Summary: Enables mRNA 3'-UTR AU-rich region binding activity; mRNA CDS binding activity; and sequence-specific mRNA binding activity. Involved in several processes, including negative regulation of cytoplasmic translation; positive regulation of cell differentiation; and regulation of mRNA metabolic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in heart (RPKM 42.8), endometrium (RPKM 14.9) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p22.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (17281361..17293871)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (17153424..17165937)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (17281592..17294102)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

YAP1-induced RBM24 promotes the tumorigenesis of triple-negative breast cancer through the beta-catenin pathway.
Title: YAP1-induced RBM24 promotes the tumorigenesis of triple-negative breast cancer through the β-catenin pathway.
Rbm24 modulates neuronal RNA splicing to restrict cognitive dysfunction.
Title: Rbm24 modulates neuronal RNA splicing to restrict cognitive dysfunction.
MiR-20a-5p targets RBM24 and alleviates hypertensive intracerebral hemorrhage.
Title: MiR-20a-5p targets RBM24 and alleviates hypertensive intracerebral hemorrhage.
RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5'-untranslated region.
Title: RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5'-untranslated region.
RBM24 controls cardiac QT interval through CaMKIIdelta splicing.
Title: RBM24 controls cardiac QT interval through CaMKIIδ splicing.
RBM24 exacerbates bladder cancer progression by forming a Runx1t1/TCF4/miR-625-5p feedback loop.
Title: RBM24 exacerbates bladder cancer progression by forming a Runx1t1/TCF4/miR-625-5p feedback loop.
Alternative Splicing Mediated by RNA-Binding Protein RBM24 Facilitates Cardiac Myofibrillogenesis in a Differentiation Stage-Specific Manner.
Title: Alternative Splicing Mediated by RNA-Binding Protein RBM24 Facilitates Cardiac Myofibrillogenesis in a Differentiation Stage-Specific Manner.
RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA.
Title: RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA.
TPRG1-AS1 induces RBM24 expression and inhibits liver cancer progression by sponging miR-4691-5p and miR-3659.
Title: TPRG1-AS1 induces RBM24 expression and inhibits liver cancer progression by sponging miR-4691-5p and miR-3659.
TRIM56 suppresses the malignant development of hepatocellular carcinoma via targeting RBM24 and inactivating the Wnt signaling.
Title: TRIM56 suppresses the malignant development of hepatocellular carcinoma via targeting RBM24 and inactivating the Wnt signaling.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of antibody response to smallpox vaccine. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:483691

STS-N39066 (e-PCR)
- UniSTS:21433

D6S1242E (e-PCR)
- UniSTS:48373

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA CDS binding	IDA Inferred from Direct Assay more info	PubMed
enables pre-mRNA intronic binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion development	IEA Inferred from Electronic Annotation more info
involved_in mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myotube differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of skeletal muscle fiber differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding protein 24

Names: RNA-binding region (RNP1, RRM) containing 6; RNA-binding region-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143941.1 → NP_001137413.1 RNA-binding protein 24 isoform 3

See identical proteins and their annotated locations for NP_001137413.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AK055391, AL136305, BC040928, BP309176

Consensus CDS

CCDS47379.1

UniProtKB/TrEMBL

H0Y8S7

Related

ENSP00000396898.2, ENST00000425446.6

Conserved Domains (1) summary

cl17169
Location:1 → 28

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001143942.2 → NP_001137414.1 RNA-binding protein 24 isoform 1

See identical proteins and their annotated locations for NP_001137414.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK315856, AL136305, BC040928

Consensus CDS

CCDS47378.1

UniProtKB/Swiss-Prot

E9PAY4, Q6QDA4, Q8N9D3, Q96NI3, Q9BX46

UniProtKB/TrEMBL

A8KAI7, H0Y8S7

Related

ENSP00000368341.5, ENST00000379052.10

Conserved Domains (1) summary

cd12384
Location:11 → 86

RRM_RBM24_RBM38_like; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein RBM24, RBM38 and similar proteins
NM_153020.2 → NP_694565.1 RNA-binding protein 24 isoform 2

See identical proteins and their annotated locations for NP_694565.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK055391, AL136305, BC040928

Consensus CDS

CCDS4538.1

UniProtKB/TrEMBL

H0Y8S7

Related

ENSP00000319551.5, ENST00000318204.5

Conserved Domains (1) summary

cl17169
Location:12 → 41

RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

17281361..17293871

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011514387.3 → XP_011512689.2 RNA-binding protein 24 isoform X1
XM_011514388.3 → XP_011512690.1 RNA-binding protein 24 isoform X2

See identical proteins and their annotated locations for XP_011512690.1

UniProtKB/TrEMBL

B7Z6B7
XM_047418369.1 → XP_047274325.1 RNA-binding protein 24 isoform X3

UniProtKB/TrEMBL

B7Z6B4

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

17153424..17165937

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054354627.1 → XP_054210602.1 RNA-binding protein 24 isoform X1
XM_054354628.1 → XP_054210603.1 RNA-binding protein 24 isoform X2

UniProtKB/TrEMBL

B7Z6B7
XM_054354629.1 → XP_054210604.1 RNA-binding protein 24 isoform X3

UniProtKB/TrEMBL

B7Z6B4