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    ZNF501 zinc finger protein 501 [ Homo sapiens (human) ]

    Gene ID: 115560, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF501provided by HGNC
    Official Full Name
    zinc finger protein 501provided by HGNC
    Primary source
    HGNC:HGNC:23717
    See related
    Ensembl:ENSG00000186446 AllianceGenome:HGNC:23717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF; ZNF52
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Involved in Golgi organization. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 2.0), ovary (RPKM 1.9) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF501 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44729635..44737083)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44745279..44752757)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44771127..44778575)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377056 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:44761628-44762827 Neighboring gene suppressor of cytokine signaling 5 pseudogene 3 Neighboring gene zinc finger protein 502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19770 Neighboring gene KIAA1143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44801624-44802266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19771 Neighboring gene kinesin family member 15 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 77

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response. Serebrenik YV, et al. Mol Biol Cell, 2018 Jun 1. PMID 29851555, Free PMC Article
    2. Characterization and mapping of human genes encoding zinc finger proteins. Bray P, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946370, Free PMC Article
    3. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Lichter P, et al. Genomics, 1992 Aug. PMID 1505991
    4. New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. Kipper S, et al. Mol Cell Proteomics, 2015 Mar. PMID 25556234, Free PMC Article
    5. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC21738

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 501
    Names
    zinc finger protein 52

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258280.2 → NP_001245209.1  zinc finger protein 501

      See identical proteins and their annotated locations for NP_001245209.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC013762, DB086337
      Consensus CDS
      CCDS2720.2
      UniProtKB/Swiss-Prot
      B4DLY7, Q96CX3, Q96NU9
      Related
      ENSP00000482632.1, ENST00000620116.5
      Conserved Domains (3) summary
      COG5048
      Location:20 → 256
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:108 → 128
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:120 → 145
      zf-H2C2_2; Zinc-finger double domain

    2. NM_145044.4 → NP_659481.2  zinc finger protein 501

      See identical proteins and their annotated locations for NP_659481.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC013762
      Consensus CDS
      CCDS2720.2
      UniProtKB/Swiss-Prot
      B4DLY7, Q96CX3, Q96NU9
      Related
      ENSP00000379363.2, ENST00000396048.6
      Conserved Domains (3) summary
      COG5048
      Location:20 → 256
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:108 → 128
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:120 → 145
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      44729635..44737083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447399.1 → XP_047303355.1  zinc finger protein 501 isoform X1

      UniProtKB/Swiss-Prot
      B4DLY7, Q96CX3, Q96NU9

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646197.1 Reference GRCh38.p14 PATCHES

      Range
      254955..262433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331541.1 → XP_054187516.1  zinc finger protein 501 isoform X1

      UniProtKB/Swiss-Prot
      B4DLY7, Q96CX3, Q96NU9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      44745279..44752757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345137.1 → XP_054201112.1  zinc finger protein 501 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96CX3.2 GenPept UniProtKB/Swiss-Prot:Q96CX3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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