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    CMKLR2 chemerin chemokine-like receptor 2 [ Homo sapiens (human) ]

    Gene ID: 2825, updated on 10-Dec-2024

    Summary

    Official Symbol
    CMKLR2provided by HGNC
    Official Full Name
    chemerin chemokine-like receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:4463
    See related
    Ensembl:ENSG00000183671 MIM:600239; AllianceGenome:HGNC:4463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR1
    Summary
    Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Predicted to be involved in glucose homeostasis and neuropeptide signaling pathway. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta (RPKM 1.8), esophagus (RPKM 1.0) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CMKLR2 in Genome Data Viewer
    Location:
    2q33.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (206175316..206217912, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (206657211..206699815, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207040040..207082636, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 beta 2 Neighboring gene small nucleolar RNA, C/D box 51 Neighboring gene small nucleolar RNA, H/ACA box 41 Neighboring gene CMKLR2 antisense RNA Neighboring gene RN7SK pseudogene 200 Neighboring gene ATP5PO pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Mesangial cells, an important component of the glomerulus, are susceptible to HIV-1 strains for which the viral gp120 protein uses GPR1 as a coreceptor PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adipokinetic hormone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables adipokinetic hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    chemerin-like receptor 2
    Names
    G protein-coupled receptor 1
    chemokine-like receptor 2
    probable G-protein coupled receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098199.2NP_001091669.1  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_001091669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BC067833, BX094581, BX389743, DA692381, DA988428
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Conserved Domains (1) summary
      cd15119
      Location:39315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001261452.2NP_001248381.1  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_001248381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK312917, BC067833, DA988428, EF577403
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Related
      ENSP00000397535.1, ENST00000437420.5
      Conserved Domains (1) summary
      cd15119
      Location:39315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001261453.2NP_001248382.1  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_001248382.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BC067833, DA545892, DA988428, EF577403
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Conserved Domains (1) summary
      cd15119
      Location:39315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001261454.1NP_001248383.1  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_001248383.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BC067833, BP279126, EF577403
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Conserved Domains (1) summary
      cd15119
      Location:39315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. NM_001261455.1NP_001248384.1  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_001248384.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK312917, BC067833, BP279126, DA733626, EF577403
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Conserved Domains (1) summary
      cd15119
      Location:39315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
    6. NM_001389445.1NP_001376374.1  chemerin-like receptor 2

      Status: VALIDATED

      Source sequence(s)
      AC007383, AK075130
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Related
      ENSP00000483003.1, ENST00000621141.5
      Conserved Domains (1) summary
      cd15119
      Location:39315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
    7. NM_005279.4NP_005270.2  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_005270.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and all other variants encode the same protein.
      Source sequence(s)
      BC067833, BX094581, BX389743, DA692381, DA988428
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Related
      ENSP00000384345.2, ENST00000407325.6
      Conserved Domains (1) summary
      cd15119
      Location:39315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      206175316..206217912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443968.1XP_047299924.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_015495299.1 Reference GRCh38.p14 PATCHES

      Range
      284334..326930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331981.1XP_054187956.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
    2. XM_054331980.1XP_054187955.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      206657211..206699815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341421.1XP_054197396.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
    2. XM_054341420.1XP_054197395.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4