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    C5AR2 complement C5a receptor 2 [ Homo sapiens (human) ]

    Gene ID: 27202, updated on 10-Dec-2024

    Summary

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    Official Symbol
    C5AR2provided by HGNC
    Official Full Name
    complement C5a receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:4527
    See related
    Ensembl:ENSG00000134830 MIM:609949; AllianceGenome:HGNC:4527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C5L2; GPF77; GPR77
    Summary
    This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
    Expression
    Broad expression in spleen (RPKM 2.6), appendix (RPKM 1.3) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C5AR2 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47332175..47347329)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (50157644..50172793)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47835432..47850586)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10852 Neighboring gene CRISPRi-validated cis-regulatory element chr19.5070 Neighboring gene InaF motif containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47793125-47793976 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:47818477-47818672 Neighboring gene Sharpr-MPRA regulatory region 10427 Neighboring gene complement C5a receptor 1 Neighboring gene Sharpr-MPRA regulatory region 4678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47852412-47853316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47858319-47858818 Neighboring gene DExH-box helicase 34 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:47895565-47896211 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:47896212-47896859 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47901415-47902082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47905147-47905846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47905847-47906546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47906547-47907244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47920878-47921870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47921871-47922864 Neighboring gene Meis homeobox 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway. Irfan M, et al. Sci Rep, 2023 Jan 2. PMID 36593314, Free PMC Article
    2. A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. Ohno M, et al. Mol Immunol, 2000 Jun. PMID 11090875
    3. The human complement fragment receptor, C5L2, is a recycling decoy receptor. Scola AM, et al. Mol Immunol, 2009 Mar. PMID 19100624, Free PMC Article
    4. C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation. Cui W, et al. Mol Immunol, 2009 Sep. PMID 19615750
    5. Relationship between a novel polymorphism of the C5L2 gene and coronary artery disease. Zheng YY, et al. PLoS One, 2011. PMID 21698200, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.
      Title: C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.
    2. C5L2 modulates BDNF production in human dental pulp stem cells via p38alpha pathway.
      Title: C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway.
    3. Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients.
      Title: Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients.
    4. C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages.
      Title: C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages.
    5. Expression of C5aR1 and C5aR2 in whole blood was significantly attenuated by IL-6R-inhibition in non-ST-elevation myocardial infarction patients.
      Title: IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.
    6. Both rs2972607 and rs8112962 SNPs of C5L2 are associated with coronary artery disease in a Han population of China.
      Title: Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.
    7. Studies indicate that the complement response lie the active fragments, C3a and C5a, acting through their specific receptors, C3aR, C5aR1 and C5aR2 to direct the cellular response to inflammation.
      Title: New concepts on the therapeutic control of complement anaphylatoxin receptors.
    8. negative regulator of BDNF secretion by pulp fibroblasts under carious teeth
      Title: C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts.
    9. All the C698T genotypes and allele frequencies in C5L2 were almost similar in both the cases and controls.
      Title: Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population.
    10. C5AR and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.
      Title: Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables complement component C5a receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement component C5a signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of interleukin-8 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    C5a anaphylatoxin chemotactic receptor 2
    Names
    C5a anaphylatoxin chemotactic receptor C5L2
    G protein-coupled receptor 77
    G protein-coupled receptor C5L2
    complement component 5a receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271749.2 → NP_001258678.1  C5a anaphylatoxin chemotactic receptor 2

      See identical proteins and their annotated locations for NP_001258678.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AB038237, AC008754, AK313994
      Consensus CDS
      CCDS12699.1
      UniProtKB/Swiss-Prot
      B2RA09, Q9P296
      UniProtKB/TrEMBL
      Q6NWQ8, Q6NWQ9
      Related
      ENSP00000472620.1, ENST00000595464.3
      Conserved Domains (1) summary
      pfam00001
      Location:52 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_001271750.2 → NP_001258679.1  C5a anaphylatoxin chemotactic receptor 2

      See identical proteins and their annotated locations for NP_001258679.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AB038237, AC008754, BP370117
      Consensus CDS
      CCDS12699.1
      UniProtKB/Swiss-Prot
      B2RA09, Q9P296
      UniProtKB/TrEMBL
      Q6NWQ8, Q6NWQ9
      Conserved Domains (1) summary
      pfam00001
      Location:52 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_018485.3 → NP_060955.1  C5a anaphylatoxin chemotactic receptor 2

      See identical proteins and their annotated locations for NP_060955.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AB038237, AC008754, DA673976
      Consensus CDS
      CCDS12699.1
      UniProtKB/Swiss-Prot
      B2RA09, Q9P296
      UniProtKB/TrEMBL
      Q6NWQ8, Q6NWQ9
      Related
      ENSP00000471184.1, ENST00000600626.1
      Conserved Domains (1) summary
      pfam00001
      Location:52 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      47332175..47347329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      50157644..50172793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P296.1 GenPept UniProtKB/Swiss-Prot:Q9P296

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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