Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ucp2provided by MGI
Official Full Name: uncoupling protein 2 (mitochondrial, proton carrier)provided by MGI
Primary source: MGI:MGI:109354
See related: Ensembl:ENSMUSG00000033685 AllianceGenome:MGI:109354
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UCPH; UCP 2; Slc25a8
Summary: Enables GDP binding activity. Involved in several processes, including cellular response to glucose stimulus; macrophage differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of neuron apoptotic process. Located in mitochondrial membrane. Is expressed in several structures, including alimentary system; cerebral cortex; hemolymphoid system; integumental system; and nose. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in stomach adult (RPKM 802.8), duodenum adult (RPKM 693.5) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.36 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (100142565..100148832)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (100493337..100499629)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UCP2 knockout exacerbates sepsis-induced intestinal injury by promoting NLRP3-mediated pyroptosis.
Title: UCP2 knockout exacerbates sepsis-induced intestinal injury by promoting NLRP3-mediated pyroptosis.
Uncoupling Protein 2 Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting Cardiomyocyte Ferroptosis.
Title: Uncoupling Protein 2 Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting Cardiomyocyte Ferroptosis.
Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2.
Title: Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2.
Loss of UCP2 causes mitochondrial fragmentation by OMA1-dependent proteolytic processing of OPA1 in podocytes.
Title: Loss of UCP2 causes mitochondrial fragmentation by OMA1-dependent proteolytic processing of OPA1 in podocytes.
UCP2 deficiency impairs podocyte autophagy in diabetic nephropathy.
Title: UCP2 deficiency impairs podocyte autophagy in diabetic nephropathy.
AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo.
Title: AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo.
UCP2-dependent redox sensing in POMC neurons regulates feeding.
Title: UCP2-dependent redox sensing in POMC neurons regulates feeding.
UCP2 KO mice exhibit ameliorated obesity and inflammation induced by high-fat diet feeding.
Title: UCP2 KO mice exhibit ameliorated obesity and inflammation induced by high-fat diet feeding.
Activating PPARbeta/delta Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model.
Title: Activating PPARβ/δ Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model.
Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis.
Title: Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis.

Submit: New GeneRIF Correction See all GeneRIFs (190)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE196958 (e-PCR)
- UniSTS:208162

PMC297000P1 (e-PCR)
- UniSTS:272452

PMC297000P2 (e-PCR)
- UniSTS:272453

Ucp2 (e-PCR), detects polymorphism
- UniSTS:547171

PMC123151P2 (e-PCR)
- UniSTS:270440

AW108044 (e-PCR)
- UniSTS:179331

Ucp2 (e-PCR), detects polymorphism
- UniSTS:531401

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables L-aspartate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-aspartate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables malate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables malate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxaloacetate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oxaloacetate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidative phosphorylation uncoupler activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate ion uniporter activity	ISO Inferred from Sequence Orthology more info
enables phosphate ion uniporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables secondary active sulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables secondary active sulfate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in C4-dicarboxylate transport	ISO Inferred from Sequence Orthology more info
involved_in C4-dicarboxylate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-aspartate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in adaptive thermogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lead ion	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glutamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium import into the mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxaloacetate(2-) transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cold	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to dexamethasone	IEA Inferred from Electronic Annotation more info
involved_in response to fatty acid	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to superoxide	IEA Inferred from Electronic Annotation more info
involved_in response to superoxide	ISO Inferred from Sequence Orthology more info
involved_in sulfate transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISA Inferred from Sequence Alignment more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dicarboxylate carrier UCP2

Names: dicarboxylate carrier SLC25A8; mitochondrial uncoupling protein 2; solute carrier family 25 member 8; uncoupling protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417452.1 → NP_001404381.1 dicarboxylate carrier UCP2

Status: VALIDATED

Source sequence(s)

AC117215

UniProtKB/Swiss-Prot

O88285, P70406

UniProtKB/TrEMBL

Q549J5, Q8CBU0, Q9R246
NM_001417453.1 → NP_001404382.1 dicarboxylate carrier UCP2

Status: VALIDATED

Source sequence(s)

AC117215

UniProtKB/Swiss-Prot

O88285, P70406

UniProtKB/TrEMBL

Q549J5, Q8CBU0, Q9R246

Related

ENSMUSP00000146337.2, ENSMUST00000207748.2
NM_001417454.1 → NP_001404383.1 dicarboxylate carrier UCP2

Status: VALIDATED

Source sequence(s)

AC117215

UniProtKB/Swiss-Prot

O88285, P70406

UniProtKB/TrEMBL

Q549J5, Q8CBU0, Q9R246
NM_001417455.1 → NP_001404384.1 dicarboxylate carrier UCP2

Status: VALIDATED

Source sequence(s)

AC117215

UniProtKB/Swiss-Prot

O88285, P70406

UniProtKB/TrEMBL

Q549J5, Q8CBU0, Q9R246
NM_011671.6 → NP_035801.3 dicarboxylate carrier UCP2

See identical proteins and their annotated locations for NP_035801.3

Status: VALIDATED

Source sequence(s)

AC117215

Consensus CDS

CCDS21498.1

UniProtKB/Swiss-Prot

O88285, P70406

UniProtKB/TrEMBL

Q549J5, Q8CBU0, Q9R246

Related

ENSMUSP00000120967.2, ENSMUST00000126534.8

Conserved Domains (1) summary

pfam00153
Location:115 → 206

Mito_carr; Mitochondrial carrier protein