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    St13 suppression of tumorigenicity 13 [ Mus musculus (house mouse) ]

    Gene ID: 70356, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St13provided by MGI
    Official Full Name
    suppression of tumorigenicity 13provided by MGI
    Primary source
    MGI:MGI:1917606
    See related
    Ensembl:ENSMUSG00000022403 AllianceGenome:MGI:1917606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HIP; HOP; p48; SNC6; HSPABP; HSPABP1; PRO0786; 1110007I03Rik; 3110002K08Rik
    Summary
    Predicted to enable several functions, including Hsp70 protein binding activity; dATP binding activity; and unfolded protein binding activity. Acts upstream of or within response to bacterium. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Orthologous to several human genes including ST13 (ST13 Hsp70 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 66.5), CNS E11.5 (RPKM 53.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St13 in Genome Data Viewer
    Location:
    15 E1; 15 38.07 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81247869..81284278, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81365044..81399694, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52179 Neighboring gene solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 Neighboring gene STARR-positive B cell enhancer mm9_chr15:81163002-81163302 Neighboring gene STARR-seq mESC enhancer starr_39251 Neighboring gene STARR-positive B cell enhancer ABC_E2445 Neighboring gene STARR-positive B cell enhancer ABC_E7396 Neighboring gene X-prolyl aminopeptidase 3, mitochondrial Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene predicted gene 17025

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis. Cao RC, et al. J Transl Med, 2022 May 13. PMID 35562743, Free PMC Article
    2. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article
    3. TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. Fan X, et al. Elife, 2021 Feb 8. PMID 33554859, Free PMC Article
    4. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
    5. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis.
      Title: St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hsc70-interacting protein
    Names
    Hsp70 interacting protein
    protein ST13 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418649.1 → NP_001405578.1  hsc70-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/Swiss-Prot
      Q4FJT4, Q99L47
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1

    2. NM_001418650.1 → NP_001405579.1  hsc70-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1

    3. NM_001418651.1 → NP_001405580.1  hsc70-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1

    4. NM_001418652.1 → NP_001405581.1  hsc70-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1

    5. NM_001418653.1 → NP_001405582.1  hsc70-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1

    6. NM_001418654.1 → NP_001405583.1  hsc70-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1

    7. NM_133726.3 → NP_598487.1  hsc70-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_598487.1

      Status: VALIDATED

      Source sequence(s)
      AC109153
      Consensus CDS
      CCDS27667.1
      UniProtKB/Swiss-Prot
      Q4FJT4, Q99L47
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1
      Related
      ENSMUSP00000130195.2, ENSMUST00000172107.8
      Conserved Domains (5) summary
      smart00727
      Location:321 → 360
      STI1; Heat shock chaperonin-binding motif
      cd14438
      Location:3 → 43
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:113 → 141
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:147 → 179
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:112 → 178
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81247869..81284278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99L47.1 GenPept UniProtKB/Swiss-Prot:Q99L47

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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