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    Psg22 pregnancy-specific beta-1-glycoprotein 22 [ Mus musculus (house mouse) ]

    Gene ID: 243862, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Psg22provided by MGI
    Official Full Name
    pregnancy-specific beta-1-glycoprotein 22provided by MGI
    Primary source
    MGI:MGI:1891354
    See related
    Ensembl:ENSMUSG00000044903 AllianceGenome:MGI:1891354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cea9
    Summary
    Enables syndecan binding activity. Acts upstream of or within positive regulation of angiogenesis; positive regulation of macrophage cytokine production; and positive regulation of transforming growth factor beta production. Predicted to be located in extracellular region. Predicted to be active in cell surface and plasma membrane. Orthologous to human CEACAM4 (CEA cell adhesion molecule 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 45.0) See more
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    Genomic context

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    See Psg22 in Genome Data Viewer
    Location:
    7 A3; 7 9.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18451976..18461363)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18718051..18727438)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pregnancy-specific beta-1-glycoprotein 21 Neighboring gene pregnancy-specific beta-1-glycoprotein 20 Neighboring gene STARR-seq mESC enhancer starr_18172 Neighboring gene STARR-seq mESC enhancer starr_18173 Neighboring gene STARR-seq mESC enhancer starr_18174 Neighboring gene STARR-seq mESC enhancer starr_18175 Neighboring gene predicted gene, 24464 Neighboring gene synaptonemal complex protein 1, pseudogene 1 Neighboring gene pregnancy specific beta-1-glycoprotein 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Early expression of pregnancy-specific glycoprotein 22 (PSG22) by trophoblast cells modulates angiogenesis in mice. Blois SM, et al. Biol Reprod, 2012 Jun. PMID 22423048, Free PMC Article
    2. Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature. Wynne F, et al. Reproduction, 2006 Apr. PMID 16595723
    3. Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle. Nakano T, et al. Dev Biol, 2021 Oct. PMID 34246625
    4. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expressed early in pregnancy with the ability to induce the secretion of proangiogenic factors in immune cell types, including uterine dendritic and NK cells
      Title: Early expression of pregnancy-specific glycoprotein 22 (PSG22) by trophoblast cells modulates angiogenesis in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91102

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syndecan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of macrophage cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of macrophage cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of transforming growth factor beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy-specific glycoprotein 22
    Names
    carcinoembryonic antigen-related cell adhesion molecule 1 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004152.3 → NP_001004152.1  pregnancy-specific glycoprotein 22 precursor

      See identical proteins and their annotated locations for NP_001004152.1

      Status: VALIDATED

      Source sequence(s)
      AC149065
      Consensus CDS
      CCDS20876.1
      UniProtKB/Swiss-Prot
      Q66JZ0, Q810J1
      UniProtKB/TrEMBL
      E9Q6J7
      Related
      ENSMUSP00000146795.2, ENSMUST00000208221.2
      Conserved Domains (2) summary
      smart00408
      Location:400 → 461
      IGc2; Immunoglobulin C-2 Type
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18451976..18461363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242558.1 → XP_030098418.1  pregnancy-specific glycoprotein 22 isoform X2

      Conserved Domains (1) summary
      cd05774
      Location:75 → 179
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    2. XM_017322233.1 → XP_017177722.1  pregnancy-specific glycoprotein 22 isoform X1

      Conserved Domains (2) summary
      smart00408
      Location:319 → 380
      IGc2; Immunoglobulin C-2 Type
      cd05774
      Location:75 → 179
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_019175.1: Suppressed sequence

      Description
      NG_019175.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810J1.2 GenPept UniProtKB/Swiss-Prot:Q810J1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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