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    Fmnl2 formin-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 71409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fmnl2provided by MGI
    Official Full Name
    formin-like 2provided by MGI
    Primary source
    MGI:MGI:1918659
    See related
    Ensembl:ENSMUSG00000036053 AllianceGenome:MGI:1918659
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Man; 5430425K04Rik
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in cell migration; cortical actin cytoskeleton organization; and regulation of cell shape. Predicted to be located in glutamatergic synapse and postsynapse. Predicted to be active in cytosol. Is expressed in brain. Orthologous to human FMNL2 (formin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 13.6), whole brain E14.5 (RPKM 12.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fmnl2 in Genome Data Viewer
    Location:
    2 C1.1; 2 30.69 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (52747743..53023816)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (52857717..53134202)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 4 subunit Neighboring gene predicted gene, 46740 Neighboring gene STARR-positive B cell enhancer ABC_E7814 Neighboring gene predicted gene, 46741 Neighboring gene STARR-positive B cell enhancer ABC_E10102 Neighboring gene signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 Neighboring gene STARR-seq mESC enhancer starr_04490 Neighboring gene STARR-seq mESC enhancer starr_04498 Neighboring gene STARR-seq mESC enhancer starr_04499 Neighboring gene predicted gene, 52511 Neighboring gene pre-mRNA processing factor 40A Neighboring gene STARR-positive B cell enhancer ABC_E1005 Neighboring gene STARR-positive B cell enhancer ABC_E7815 Neighboring gene STARR-positive B cell enhancer ABC_E7816 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FMNL2 regulates actin for endoplasmic reticulum and mitochondria distribution in oocyte meiosis. Pan MH, et al. Elife, 2024 May 15. PMID 38747713, Free PMC Article
    2. Formins regulate actin filament flexibility through long range allosteric interactions. Bugyi B, et al. J Biol Chem, 2006 Apr 21. PMID 16490788, Free PMC Article
    3. Critical roles for multiple formins during cardiac myofibril development and repair. Rosado M, et al. Mol Biol Cell, 2014 Mar. PMID 24430873, Free PMC Article
    4. FMNL formins boost lamellipodial force generation. Kage F, et al. Nat Commun, 2017 Mar 22. PMID 28327544, Free PMC Article
    5. Caveolin-1 influences epithelial collective cell migration via FMNL2 formin. Katsuno-Kambe H, et al. Biol Cell, 2021 Feb. PMID 33169848

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FMNL2 regulates actin for endoplasmic reticulum and mitochondria distribution in oocyte meiosis.
      Title: FMNL2 regulates actin for endoplasmic reticulum and mitochondria distribution in oocyte meiosis.
    2. Caveolin-1 influences epithelial collective cell migration via FMNL2 formin.
      Title: Caveolin-1 influences epithelial collective cell migration via FMNL2 formin.
    3. Our data thus link FMNL2/3 formins to actin assembly-dependent functions of Cdc42 in anterograde transport through the Golgi apparatus.
      Title: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.
    4. force generation in lamellipodia strongly depends on FMNL formin activity.
      Title: FMNL formins boost lamellipodial force generation.
    5. FMNL1 and FMNL2 are required non-redundantly in the repair of damaged myofibrils.
      Title: Critical roles for multiple formins during cardiac myofibril development and repair.
    6. FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia.
      Title: FMNL2 drives actin-based protrusion and migration downstream of Cdc42.
    7. mDia1-FH2 has an effect on the conformation of actin filaments
      Title: Formins regulate actin filament flexibility through long range allosteric interactions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cortical actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    formin-like protein 2
    Names
    formin-like domain containing protein MAN
    protein Man

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408315.1 → NP_001395244.1  formin-like protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL844510, AL844859, AL845170
      Related
      ENSMUSP00000088472.5, ENSMUST00000090952.11

    2. NM_001408316.1 → NP_001395245.1  formin-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844510, AL844859, AL845170
      UniProtKB/Swiss-Prot
      A2APV2, A2AQW1, Q69Z73, Q7TPA8, Q80VH6
      Related
      ENSMUSP00000118658.3, ENSMUST00000127122.9

    3. NM_001408317.1 → NP_001395246.1  formin-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL844510, AL844859, AL845170

    4. NM_172409.3 → NP_765997.2  formin-like protein 2 isoform 3

      See identical proteins and their annotated locations for NP_765997.2

      Status: VALIDATED

      Source sequence(s)
      AL844510, AL844859, AL845170
      Consensus CDS
      CCDS38124.1
      UniProtKB/TrEMBL
      F8VPR2
      Related
      ENSMUSP00000047260.7, ENSMUST00000049483.14
      Conserved Domains (3) summary
      pfam02181
      Location:615 → 966
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      52747743..53023816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498336.3 → XP_006498399.1  formin-like protein 2 isoform X8

      Conserved Domains (3) summary
      pfam02181
      Location:571 → 922
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:227 → 424
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:23 → 224
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. XM_006498332.4 → XP_006498395.1  formin-like protein 2 isoform X3

      Conserved Domains (3) summary
      pfam02181
      Location:622 → 973
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    3. XM_006498331.4 → XP_006498394.1  formin-like protein 2 isoform X2

      Conserved Domains (3) summary
      pfam02181
      Location:622 → 973
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    4. XM_006498334.4 → XP_006498397.1  formin-like protein 2 isoform X5

      Conserved Domains (3) summary
      pfam02181
      Location:622 → 973
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    5. XM_006498330.3 → XP_006498393.1  formin-like protein 2 isoform X1

      Conserved Domains (3) summary
      pfam02181
      Location:622 → 973
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    6. XM_006498335.5 → XP_006498398.1  formin-like protein 2 isoform X7

      UniProtKB/TrEMBL
      A2AQW2
      Related
      ENSMUSP00000117822.3, ENSMUST00000155586.9
      Conserved Domains (3) summary
      pfam02181
      Location:615 → 966
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain

    7. XM_006498337.5 → XP_006498400.1  formin-like protein 2 isoform X9

      Conserved Domains (3) summary
      pfam06367
      Location:278 → 475
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:23 → 275
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:622 → 806
      FH2; Formin Homology 2 Domain

    RNA

    1. XR_003953721.2 RNA Sequence

    2. XR_004940731.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2APV2.2 GenPept UniProtKB/Swiss-Prot:A2APV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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