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    Lman2l lectin, mannose-binding 2-like [ Mus musculus (house mouse) ]

    Gene ID: 214895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lman2lprovided by MGI
    Official Full Name
    lectin, mannose-binding 2-likeprovided by MGI
    Primary source
    MGI:MGI:2443010
    See related
    Ensembl:ENSMUSG00000001143 AllianceGenome:MGI:2443010
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    VIPL; VIP36-like; A630028F14Rik
    Summary
    Predicted to enable D-mannose binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein transport. Predicted to be located in Golgi apparatus. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal recessive intellectual developmental disorder 52. Orthologous to human LMAN2L (lectin, mannose binding 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.1), whole brain E14.5 (RPKM 9.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lman2l in Genome Data Viewer
    Location:
    1 B; 1 15.26 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36458274..36484352, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36418900..36445271, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2541 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36364755-36365011 Neighboring gene AT-rich interaction domain 5A Neighboring gene KAT8 regulatory NSL complex subunit 3 Neighboring gene microRNA 6898 Neighboring gene fer-1 like family member 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36501343-36501452 Neighboring gene STARR-positive B cell enhancer ABC_E5746 Neighboring gene predicted gene, 33401 Neighboring gene predicted gene, 33454 Neighboring gene cyclin M4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp564L2423

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    VIP36-like protein
    Names
    LMAN2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013374.2 → NP_001013392.1  VIP36-like protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_001013392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) lacks an alternate in-frame exon compared to variant 1.
      Source sequence(s)
      AC084391, BC046969
      Consensus CDS
      CCDS14878.1
      UniProtKB/Swiss-Prot
      P59481, Q3TZ91
      Related
      ENSMUSP00000117200.2, ENSMUST00000125304.8
      Conserved Domains (1) summary
      cl14058
      Location:49 → 297
      lectin_L-type; legume lectins

    2. NM_001310517.1 → NP_001297446.1  VIP36-like protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_001297446.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC084391, AK158015, BC046969, CB248466
      Consensus CDS
      CCDS78563.1
      UniProtKB/TrEMBL
      D3Z4P2
      Related
      ENSMUSP00000110663.2, ENSMUST00000115011.8
      Conserved Domains (1) summary
      cl14058
      Location:49 → 308
      lectin_L-type; legume lectins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      36458274..36484352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252925.2 → XP_030108785.1  VIP36-like protein isoform X2

      Conserved Domains (1) summary
      cl14058
      Location:1 → 160
      lectin_L-type; legume lectins

    2. XM_006495854.5 → XP_006495917.1  VIP36-like protein isoform X1

      Conserved Domains (1) summary
      cl14058
      Location:1 → 171
      lectin_L-type; legume lectins

    3. XM_006495855.5 → XP_006495918.1  VIP36-like protein isoform X2

      Conserved Domains (1) summary
      cl14058
      Location:1 → 160
      lectin_L-type; legume lectins

    4. XM_017319753.3 → XP_017175242.1  VIP36-like protein isoform X1

      Conserved Domains (1) summary
      cl14058
      Location:1 → 171
      lectin_L-type; legume lectins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59481.1 GenPept UniProtKB/Swiss-Prot:P59481

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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