Rad54l RAD54 like (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rad54lprovided by MGI
Official Full Name: RAD54 like (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:894697
See related: Ensembl:ENSMUSG00000028702 AllianceGenome:MGI:894697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RAD54
Summary: Predicted to enable ATP-dependent DNA/DNA annealing activity and DNA translocase activity. Acts upstream of or within several processes, including determination of adult lifespan; double-strand break repair via homologous recombination; and response to ionizing radiation. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; incisor; metencephalon rest of alar plate marginal layer; submandibular gland primordium; and thymus primordium. Used to study sclerocornea. Human ortholog(s) of this gene implicated in breast cancer; disease of cellular proliferation; non-Hodgkin lymphoma; and pancreatic cancer. Orthologous to human RAD54L (RAD54 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 12.3), testis adult (RPKM 10.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.1 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (115951458..115980875, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (116094261..116123700, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our study highlights the importance of the cooperation between Rad54 and Mus81 for mediating DNA DSB repair and restraining chromosome missegregation.
Title: Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.
These results reveal a differential interaction of the ATM-mediated DNA damage response and Rad54 paralog-mediated homologous recombination depending on the DNA damaging agent that initiates the response.
Title: Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.
Mus81-Eme1- and Rad54-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway
Title: The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks.
Rad54 is not required for either transgene isotype switching or transgene hypermutation.
Title: Gene conversion-like sequence transfers between transgenic antibody V genes are independent of RAD54.
Rad54-mediated homologous recombination is not essential for somatic hypermutation. In addition, the finding that the ablation of RAD51 paralogues causes an increase in SHM argues against a direct involvement of HR in promoting SHM.
Title: Somatic hypermutation does not require Rad54 and Rad54B-mediated homologous recombination.
Rad54 cooperates with DNA Ligase IV to support cellular proliferation, dna repair, and prevent chromosome and single chromatid aberrations
Title: Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability.
Rad54 has a role in telomere length maintenance
Title: Role of mammalian Rad54 in telomere length maintenance.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235013

RH125906 (e-PCR)
- UniSTS:162628

RH127472 (e-PCR)
- UniSTS:210782

AW555107 (e-PCR)
- UniSTS:179057

RH124910 (e-PCR)
- UniSTS:161732

SHGC-74777 (e-PCR)
- UniSTS:25560

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA/DNA annealing activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent DNA/DNA annealing activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA translocase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within double-strand break repair	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within double-strand break repair via homologous recombination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via synthesis-dependent strand annealing	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to ionizing radiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA repair and recombination protein RAD54-like

Names: RAD54 homolog; mHR54; mRAD54

NP_001116430.1

EC 3.6.4.12

NP_001116431.1

EC 3.6.4.12

NP_001411773.1

EC 3.6.4.12

NP_001411774.1

EC 3.6.4.12

NP_001411775.1

EC 3.6.4.12

NP_001411776.1

EC 3.6.4.12

NP_001411777.1

EC 3.6.4.12

NP_033041.3

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122958.2 → NP_001116430.1 DNA repair and recombination protein RAD54-like isoform 1

See identical proteins and their annotated locations for NP_001116430.1

Status: VALIDATED

Source sequence(s)

AL611947, AL627105

Consensus CDS

CCDS18504.1

UniProtKB/Swiss-Prot

P70270, Q8BSR5, Q8C2C4, Q8K3D4

Related

ENSMUSP00000099766.4, ENSMUST00000102705.10

Conserved Domains (3) summary

COG0553
Location:107 → 668

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd18067
Location:153 → 395

DEXHc_RAD54A; DEXH-box helicase domain of RAD54A

pfam08658
Location:76 → 123

Rad54_N; Rad54 N terminal
NM_001122959.2 → NP_001116431.1 DNA repair and recombination protein RAD54-like isoform 1

See identical proteins and their annotated locations for NP_001116431.1

Status: VALIDATED

Source sequence(s)

AL611947, AL627105

Consensus CDS

CCDS18504.1

UniProtKB/Swiss-Prot

P70270, Q8BSR5, Q8C2C4, Q8K3D4

Conserved Domains (3) summary

COG0553
Location:107 → 668

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd18067
Location:153 → 395

DEXHc_RAD54A; DEXH-box helicase domain of RAD54A

pfam08658
Location:76 → 123

Rad54_N; Rad54 N terminal
NM_001424844.1 → NP_001411773.1 DNA repair and recombination protein RAD54-like isoform 1

Status: VALIDATED

Source sequence(s)

AL611947, AL627105

UniProtKB/Swiss-Prot

P70270, Q8BSR5, Q8C2C4, Q8K3D4
NM_001424845.1 → NP_001411774.1 DNA repair and recombination protein RAD54-like isoform 1

Status: VALIDATED

Source sequence(s)

AL611947, AL627105

UniProtKB/Swiss-Prot

P70270, Q8BSR5, Q8C2C4, Q8K3D4
NM_001424846.1 → NP_001411775.1 DNA repair and recombination protein RAD54-like isoform 2

Status: VALIDATED

Source sequence(s)

AL611947, AL627105
NM_001424847.1 → NP_001411776.1 DNA repair and recombination protein RAD54-like isoform 2

Status: VALIDATED

Source sequence(s)

AL611947, AL627105
NM_001424848.1 → NP_001411777.1 DNA repair and recombination protein RAD54-like isoform 2

Status: VALIDATED

Source sequence(s)

AL611947, AL627105
NM_009015.4 → NP_033041.3 DNA repair and recombination protein RAD54-like isoform 1

See identical proteins and their annotated locations for NP_033041.3

Status: VALIDATED

Source sequence(s)

AL611947, AL627105

Consensus CDS

CCDS18504.1

UniProtKB/Swiss-Prot

P70270, Q8BSR5, Q8C2C4, Q8K3D4

Related

ENSMUSP00000099765.4, ENSMUST00000102704.4

Conserved Domains (3) summary

COG0553
Location:107 → 668

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd18067
Location:153 → 395

DEXHc_RAD54A; DEXH-box helicase domain of RAD54A

pfam08658
Location:76 → 123

Rad54_N; Rad54 N terminal