Spdya speedy/RINGO cell cycle regulator family, member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spdyaprovided by MGI
Official Full Name: speedy/RINGO cell cycle regulator family, member Aprovided by MGI
Primary source: MGI:MGI:1918141
See related: Ensembl:ENSMUSG00000052525 AllianceGenome:MGI:1918141
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GS4; Spdy1; MLZ-465; 4921517J08Rik; 4930548B21Rik
Summary: Enables protein kinase activator activity and protein kinase binding activity. Involved in male meiotic nuclear division and positive regulation of cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including chromosome organization; establishment of protein localization to telomere; and spermatogenesis. Located in XY body; chromosome, telomeric region; and nuclear envelope. Is expressed in reproductive system. Orthologous to human SPDYA (speedy/RINGO cell cycle regulator family member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 7.5), CNS E18 (RPKM 0.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.3; 17 41.87 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (71833890..71896528)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (71526895..71589533)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1.
Title: SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1.
The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Title: The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Cyclin-like proteins tip regenerative balance in the liver to favour cancer formation.
Title: Cyclin-like proteins tip regenerative balance in the liver to favour cancer formation.
Spy1 plays a protective role in ALS motor neurons
Title: Spy1, a unique cell cycle regulator, alters viability in ALS motor neurons and cell lines in response to mutant SOD1-induced DNA damage.
Identified a telomere localization domain on Speedy A covering the distal N terminus and the Cdk2-binding Ringo domain, and this domain is essential for the localization of Speedy A to telomeres.
Title: Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation.
RingoA is an important activator of Cdk2 at meiotic telomeres.
Title: Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope.
the Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast
Title: The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit52.1 (e-PCR), detects polymorphism
- UniSTS:126233

NoName (e-PCR)
- UniSTS:237689

NoName (e-PCR)
- UniSTS:493189

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of protein localization to telomere	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiotic nuclear division	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in XY body	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: speedy protein A

Names: RINGO A; mSpy/Ringo A; protein expressed in male leptotene and zygotene spermatocytes 465; rapid inducer of G2/M progression in oocytes A; speedy A; speedy A1; speedy A2; speedy homolog 1; speedy homolog A; speedy-1; spermatogenesis related protein Gs4; spy1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142631.1 → NP_001136103.1 speedy protein A isoform 2

See identical proteins and their annotated locations for NP_001136103.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.

Source sequence(s)

AK077138

Consensus CDS

CCDS50179.1

UniProtKB/TrEMBL

B2RWC8, B8JJB9

Related

ENSMUSP00000118426.2, ENSMUST00000124001.8

Conserved Domains (1) summary

pfam11357
Location:68 → 198

Spy1; Cell cycle regulatory protein
NM_029254.1 → NP_083530.1 speedy protein A isoform 1

See identical proteins and their annotated locations for NP_083530.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AK077138, CT010429

Consensus CDS

CCDS50178.1

UniProtKB/Swiss-Prot

B8JJC0, Q5IBH7, Q5IBH8, Q8C5T5

UniProtKB/TrEMBL

B8JJB9

Related

ENSMUSP00000125912.2, ENSMUST00000167641.8

Conserved Domains (1) summary

pfam11357
Location:71 → 198

Spy1; Cell cycle regulatory protein