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    Zfp280b zinc finger protein 280B [ Mus musculus (house mouse) ]

    Gene ID: 64453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp280bprovided by MGI
    Official Full Name
    zinc finger protein 280Bprovided by MGI
    Primary source
    MGI:MGI:1927865
    See related
    Ensembl:ENSMUSG00000049764 AllianceGenome:MGI:1927865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Suhw2; D10Jhu82e
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZNF280B (zinc finger protein 280B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 9.7), ovary adult (RPKM 7.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp280b in Genome Data Viewer
    Location:
    10 C1; 10 38.67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75868235..75878804)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76032401..76042970)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40698 Neighboring gene predicted gene 5134 Neighboring gene STARR-seq mESC enhancer starr_27167 Neighboring gene STARR-positive B cell enhancer ABC_E8345 Neighboring gene STARR-seq mESC enhancer starr_27168 Neighboring gene microRNA 6409 Neighboring gene STARR-seq mESC enhancer starr_27169 Neighboring gene STARR-positive B cell enhancer ABC_E3892 Neighboring gene STARR-seq mESC enhancer starr_27170 Neighboring gene STARR-seq mESC enhancer starr_27172 Neighboring gene solute carrier family 5 (neutral amino acid transporters, system A), member 4b Neighboring gene predicted gene 16222 Neighboring gene STARR-seq mESC enhancer starr_27174 Neighboring gene solute carrier family 5 (neutral amino acid transporters, system A), member 4b pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Chromosome evolution: the junction of mammalian chromosomes in the formation of mouse chromosome 10. Pletcher MT, et al. Genome Res, 2000 Oct. PMID 11042146, Free PMC Article
    2. A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Endoh-Yamagami S, et al. Dev Biol, 2010 Apr 1. PMID 20096683
    3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 280b
    Names
    suppressor of hairy wing homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177475.3 → NP_803426.2  zinc finger protein 280b

      See identical proteins and their annotated locations for NP_803426.2

      Status: VALIDATED

      Source sequence(s)
      AC134382, AK079824, BC094574
      Consensus CDS
      CCDS23942.1
      UniProtKB/TrEMBL
      Q3UMQ7, Q505F4
      Related
      ENSMUSP00000056340.7, ENSMUST00000061617.7
      Conserved Domains (2) summary
      sd00017
      Location:336 → 357
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:53 → 221
      DUF4195; Domain of unknown function (DUF4195)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75868235..75878804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155940.1 → XP_036011833.1  zinc finger protein 280b isoform X1

      UniProtKB/TrEMBL
      Q3UMQ7, Q505F4
      Conserved Domains (2) summary
      sd00017
      Location:336 → 357
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:53 → 221
      DUF4195; Domain of unknown function (DUF4195)

    2. XM_006513942.2 → XP_006514005.1  zinc finger protein 280b isoform X1

      See identical proteins and their annotated locations for XP_006514005.1

      UniProtKB/TrEMBL
      Q3UMQ7, Q505F4
      Conserved Domains (2) summary
      sd00017
      Location:336 → 357
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:53 → 221
      DUF4195; Domain of unknown function (DUF4195)

    3. XM_006513943.2 → XP_006514006.1  zinc finger protein 280b isoform X1

      See identical proteins and their annotated locations for XP_006514006.1

      UniProtKB/TrEMBL
      Q3UMQ7, Q505F4
      Conserved Domains (2) summary
      sd00017
      Location:336 → 357
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:53 → 221
      DUF4195; Domain of unknown function (DUF4195)
    Nucleotide Protein Strain
    Heading Accession and Version

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