Nectin4 nectin cell adhesion molecule 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nectin4provided by MGI
Official Full Name: nectin cell adhesion molecule 4provided by MGI
Primary source: MGI:MGI:1918990
See related: Ensembl:ENSMUSG00000006411 AllianceGenome:MGI:1918990
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prr4; Pvrl4; 1200017F15Rik
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in plasma membrane. Predicted to be active in adherens junction. Is expressed in several structures, including alimentary system; genitourinary system; nose; respiratory system; and skin. Orthologous to human NECTIN4 (nectin cell adhesion molecule 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 13.9), genital fat pad adult (RPKM 9.3) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.37 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171197741..171215855)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171370173..171388287)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nectin4 is a potential therapeutic target for asthma.
Title: Nectin4 is a potential therapeutic target for asthma.
Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1.
Title: Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1.
nectin-4 serves as a stimulatory co-receptor for the prolactin receptor by regulating the feedback inhibition of SOCS1 in the JAK2-STAT5a signaling pathway
Title: Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway.
Novel type of cell adhesion apparatus is mediated by Nectin-1 and Nectin-4. It's implicated in prolactin receptor signaling for mammary gland development.
Title: A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development.
Pvrl1 is a bona fide target gene of the transcription factor p63, whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6
Title: p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis.
Mouse PVRL4 functions less efficiently as a receptor for measles virus than the human homologue.
Title: Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus.
Ectodermal dysplasia-syndactyly syndrome is the second known "nectinopathy" caused by mutations in a nectin adhesion molecule.
Title: Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nectin-4

Names: ig superfamily receptor LNIR; nectin 4; poliovirus receptor-related 4; poliovirus receptor-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122680.1 → NP_001116152.1 nectin-4 isoform b precursor

See identical proteins and their annotated locations for NP_001116152.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.

Source sequence(s)

AK004821, AK028479, BX638135, BY154786

Consensus CDS

CCDS48442.1

UniProtKB/Swiss-Prot

Q8R007

Related

ENSMUSP00000091883.5, ENSMUST00000094325.5

Conserved Domains (4) summary

cd00096
Location:265 → 328

Ig; Immunoglobulin domain

cd07704
Location:148 → 241

Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins

smart00410
Location:258 → 331

IG_like; Immunoglobulin like

cl11960
Location:45 → 145

Ig; Immunoglobulin domain
NM_027893.3 → NP_082169.2 nectin-4 isoform a precursor

See identical proteins and their annotated locations for NP_082169.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).

Source sequence(s)

AK004821, AK028479, BX638135, BY154786

Consensus CDS

CCDS15493.1

UniProtKB/Swiss-Prot

Q3U318, Q8CED8, Q8R007, Q9DBP8

Related

ENSMUSP00000006578.4, ENSMUST00000006578.10

Conserved Domains (4) summary

cd00096
Location:265 → 328

Ig; Immunoglobulin domain

cd07704
Location:148 → 241

Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins

smart00410
Location:258 → 331

IG_like; Immunoglobulin like

cl11960
Location:45 → 145

Ig; Immunoglobulin domain