Gstm6 glutathione S-transferase, mu 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstm6provided by MGI
Official Full Name: glutathione S-transferase, mu 6provided by MGI
Primary source: MGI:MGI:1309467
See related: Ensembl:ENSMUSG00000068762 AllianceGenome:MGI:1309467
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including glutathione binding activity; glutathione transferase activity; and protein homodimerization activity. Predicted to be involved in several processes, including cellular detoxification of nitrogen compound; fatty acid metabolic process; and glutathione derivative biosynthetic process. Predicted to be located in cytosol and intercellular bridge. Is expressed in several structures, including genitourinary system; heart; intestine; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 42.7), genital fat pad adult (RPKM 32.0) and 7 other tissues See more
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Genomic context

Location:: 3 F2.3; 3 46.83 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (107846163..107860957, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (107938847..107953641, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gstm6 (e-PCR), detects polymorphism
- UniSTS:526845

Gstm6 (e-PCR), detects polymorphism
- UniSTS:526846

Gstm6 (e-PCR), detects polymorphism
- UniSTS:526847

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular detoxification of nitrogen compound	ISO Inferred from Sequence Orthology more info
involved_in glutathione derivative biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hepoxilin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in nitrobenzene metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione S-transferase Mu 6

Names: GST class-mu 6; glutathione-S-transferase class M5

NP_001366433.1

EC 2.5.1.18

NP_001366434.1

EC 2.5.1.18

NP_001366435.1

EC 2.5.1.18

NP_001366436.1

EC 2.5.1.18

NP_001366437.1

EC 2.5.1.18

NP_001366438.1

EC 2.5.1.18

NP_001366439.1

EC 2.5.1.18

NP_032210.3

EC 2.5.1.18

XP_006501086.1

EC 2.5.1.18

XP_006501088.1

EC 2.5.1.18

XP_030108293.1

EC 2.5.1.18

XP_036018796.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379504.1 → NP_001366433.1 glutathione S-transferase Mu 6 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC079042

UniProtKB/TrEMBL

Q9D5J8

Conserved Domains (3) summary

cd03209
Location:127 → 247

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:48 → 119

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

cl02776
Location:10 → 47

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
NM_001379505.1 → NP_001366434.1 glutathione S-transferase Mu 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC079042

UniProtKB/TrEMBL

Q9D5J8

Conserved Domains (2) summary

cd03209
Location:106 → 226

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:19 → 98

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
NM_001379506.1 → NP_001366435.1 glutathione S-transferase Mu 6 isoform 3

Status: VALIDATED

Source sequence(s)

AC079042

UniProtKB/TrEMBL

G5E8M7, Q9D5J8

Related

ENSMUSP00000102295.2, ENSMUST00000106684.8

Conserved Domains (2) summary

cd03209
Location:92 → 226

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:3 → 84

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
NM_001379507.1 → NP_001366436.1 glutathione S-transferase Mu 6 isoform 5

Status: VALIDATED

Source sequence(s)

AC079042

UniProtKB/TrEMBL

Q9D5J8

Conserved Domains (2) summary

cd03209
Location:90 → 210

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:11 → 82

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
NM_001379508.1 → NP_001366437.1 glutathione S-transferase Mu 6 isoform 6

Status: VALIDATED

Source sequence(s)

AC079042

UniProtKB/TrEMBL

D3YVP9

Related

ENSMUSP00000102292.2, ENSMUST00000106681.3

Conserved Domains (2) summary

cd03209
Location:58 → 178

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cl00388
Location:1 → 50

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
NM_001379509.1 → NP_001366438.1 glutathione S-transferase Mu 6 isoform 7

Status: VALIDATED

Source sequence(s)

AC079042

Conserved Domains (2) summary

cl00388
Location:3 → 59

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

cl02776
Location:60 → 151

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
NM_001379510.1 → NP_001366439.1 glutathione S-transferase Mu 6 isoform 8

Status: VALIDATED

Source sequence(s)

AC079042

UniProtKB/TrEMBL

D3YVP8

Related

ENSMUSP00000102294.2, ENSMUST00000106683.8

Conserved Domains (2) summary

cl00388
Location:1 → 25

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

cl02776
Location:26 → 117

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
NM_008184.4 → NP_032210.3 glutathione S-transferase Mu 6 isoform 4

See identical proteins and their annotated locations for NP_032210.3

Status: VALIDATED

Source sequence(s)

AC079042

Consensus CDS

CCDS38596.1

UniProtKB/Swiss-Prot

O35660, O35661, Q8K0C3

UniProtKB/TrEMBL

Q9D5J8

Related

ENSMUSP00000102296.3, ENSMUST00000106685.9

Conserved Domains (3) summary

PTZ00057
Location:3 → 202

PTZ00057; glutathione s-transferase; Provisional

cd03209
Location:92 → 212

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:3 → 84

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

107846163..107860957 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162903.1 → XP_036018796.1 glutathione S-transferase Mu 6 isoform X3

Conserved Domains (2) summary

cl00388
Location:11 → 57

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

cl02776
Location:58 → 149

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
XM_006501025.4 → XP_006501088.1 glutathione S-transferase Mu 6 isoform X2

Conserved Domains (2) summary

cl00388
Location:48 → 94

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

cl02776
Location:95 → 186

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
XM_006501023.1 → XP_006501086.1 glutathione S-transferase Mu 6 isoform X1

UniProtKB/TrEMBL

Q9D5J8

Conserved Domains (3) summary

cd03209
Location:101 → 221

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:22 → 93

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

cl02776
Location:1 → 21

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
XM_030252433.1 → XP_030108293.1 glutathione S-transferase Mu 6 isoform X4

Conserved Domains (2) summary

cd03075
Location:48 → 119

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

cl02776
Location:10 → 47

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family