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    4921509C19Rik RIKEN cDNA 4921509C19 gene [ Mus musculus (house mouse) ]

    Gene ID: 381393, updated on 27-Nov-2024

    Summary

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    Official Symbol
    4921509C19Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 4921509C19 geneprovided by MGI
    Primary source
    MGI:MGI:2685851
    See related
    Ensembl:ENSMUSG00000061525 AllianceGenome:MGI:2685851
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1005
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Is expressed in testis. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 29.3) See more
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    Genomic context

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    See 4921509C19Rik in Genome Data Viewer
    Location:
    2 G3; 2 74.83 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (151302301..151318188, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (151462048..151476268, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100125594 Neighboring gene predicted gene, 24868 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene STARR-seq mESC enhancer starr_06030 Neighboring gene STARR-positive B cell enhancer ABC_E11168 Neighboring gene NSFL1 (p97) cofactor (p47) Neighboring gene predicted gene, 52533

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Caenepeel S, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289607, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. First described as a mouse-specific duplication of the MARK kinase family, and named MarkmE1
      Title: The mouse kinome: discovery and comparative genomics of all mouse protein kinases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sperm motility kinase X
    Names
    MarkmE1
    NP_941057.1
    XP_006499881.1
    XP_006499883.1
    XP_036018235.1
    XP_036018236.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198655.2 → NP_941057.1  sperm motility kinase X

      See identical proteins and their annotated locations for NP_941057.1

      Status: PROVISIONAL

      Source sequence(s)
      AL928719
      Consensus CDS
      CCDS38271.1
      UniProtKB/Swiss-Prot
      Q8C0X8
      Related
      ENSMUSP00000079030.3, ENSMUST00000080132.3
      Conserved Domains (2) summary
      cd14337
      Location:290 → 328
      UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
      cd14003
      Location:23 → 270
      STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      151302301..151318188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162342.1 → XP_036018235.1  sperm motility kinase X isoform X1

      UniProtKB/Swiss-Prot
      Q8C0X8
      Conserved Domains (2) summary
      cd14337
      Location:290 → 328
      UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
      cd14003
      Location:23 → 270
      STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

    2. XM_036162343.1 → XP_036018236.1  sperm motility kinase X isoform X2

      Conserved Domains (2) summary
      cd14337
      Location:290 → 328
      UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
      cd14003
      Location:23 → 270
      STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

    3. XM_006499820.2 → XP_006499883.1  sperm motility kinase X isoform X1

      See identical proteins and their annotated locations for XP_006499883.1

      UniProtKB/Swiss-Prot
      Q8C0X8
      Conserved Domains (2) summary
      cd14337
      Location:290 → 328
      UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
      cd14003
      Location:23 → 270
      STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

    4. XM_006499818.2 → XP_006499881.1  sperm motility kinase X isoform X1

      See identical proteins and their annotated locations for XP_006499881.1

      UniProtKB/Swiss-Prot
      Q8C0X8
      Conserved Domains (2) summary
      cd14337
      Location:290 → 328
      UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
      cd14003
      Location:23 → 270
      STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0X8.1 GenPept UniProtKB/Swiss-Prot:Q8C0X8

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