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    Mpp4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) [ Mus musculus (house mouse) ]

    Gene ID: 227157, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mpp4provided by MGI
    Official Full Name
    membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)provided by MGI
    Primary source
    MGI:MGI:2386681
    See related
    Ensembl:ENSMUSG00000079550 AllianceGenome:MGI:2386681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlg6
    Summary
    Predicted to enable signaling receptor binding activity. Acts upstream of or within protein localization to synapse. Located in several cellular components, including cone cell pedicle; lateral plasma membrane; and rod spherule. Is expressed in several structures, including cerebellum; early embryo; and neural retina. Orthologous to human MPP4 (MAGUK p55 scaffold protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.2), liver adult (RPKM 3.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mpp4 in Genome Data Viewer
    Location:
    1 C1.3; 1 29.2 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59160094..59202548, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59120935..59163389, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene predicted gene, 25502 Neighboring gene transmembrane protein 237 Neighboring gene STARR-seq mESC enhancer starr_01030 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59219938-59220121 Neighboring gene predicted gene, 19125 Neighboring gene alsin Rho guanine nucleotide exchange factor Neighboring gene STARR-positive B cell enhancer ABC_E1993 Neighboring gene predicted gene, 33667 Neighboring gene STARR-seq mESC enhancer starr_01032 Neighboring gene cyclin dependent kinase 15 Neighboring gene VISTA enhancer mm1575 Neighboring gene VISTA enhancer mm489 Neighboring gene predicted gene, 51625

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spatial distribution of mDLG6 mRNA in embryonic and adult mouse brain. Inagaki H, et al. Cell Biol Int, 2002. PMID 12127943
    2. Developmental and tissue expression patterns of mouse Mpp4 gene. Li M, et al. Biochem Biophys Res Commun, 2003 Jul 25. PMID 12859944
    3. Cellular localization of the MPP4 protein in the mammalian retina. Stöhr H, et al. Invest Ophthalmol Vis Sci, 2003 Dec. PMID 14638699
    4. Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Yang J, et al. Hum Mol Genet, 2007 May 1. PMID 17341488
    5. Characterization of MPP4, a gene highly expressed in photoreceptor cells, and mutation analysis in retinitis pigmentosa. Conte I, et al. Gene, 2002 Sep 4. PMID 12384283

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that both scaffold proteins PSD95beta and MPP4 are essential for the modulation of PMCA levels at the presynaptic plasma membrane and thereby influence the photoreceptor synaptic calcium handling.
      Title: PSD95beta regulates plasma membrane Ca2+ pump localization at the photoreceptor synapse.
    2. These findings suggest that Mpp4 coordinates Psd95/Veli3 assembly and maintenance at synaptic membranes. Mpp4 is a critical recruitment factor to organize scaffolds at the photoreceptor synapse.
      Title: Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse.
    3. Results show that Mpp4 organizes a presynaptic protein complex and has a role in modulating Ca(2+) homeostasis and synaptic transmission in rod photoreceptors.
      Title: Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals.
    4. Results describe the temporal and spatial expression patterns of mouse membrane palmitoylated protein 4 (Mpp4) gene.
      Title: Developmental and tissue expression patterns of mouse Mpp4 gene.
    5. Association of Veli3 with MPP4 suggests that the MAGUKs recruit Veli3 and its binding partners to different cellular regions of the retina where they may participate in the organization of specialized intercellular junctions.
      Title: Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cone cell pedicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rod spherule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAGUK p55 subfamily member 4
    Names
    discs large homolog 6
    mDLG6
    membrane palmitoylated protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164682.2 → NP_001158154.1  MAGUK p55 subfamily member 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC133162, AC153652
      Consensus CDS
      CCDS48272.1
      UniProtKB/TrEMBL
      D3Z0G8, K3W4N9
      Related
      ENSMUSP00000109914.3, ENSMUST00000114275.9
      Conserved Domains (6) summary
      smart00569
      Location:66 → 100
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12034
      Location:264 → 324
      SH3_MPP4; Src Homology 3 domain of Membrane Protein, Palmitoylated 4 (or MAGUK p55 subfamily member 4)
      smart00072
      Location:454 → 637
      GuKc; Guanylate kinase homologues
      cd00992
      Location:171 → 250
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:446 → 636
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:108 → 154
      L27; L27 domain

    2. NM_145143.3 → NP_660125.2  MAGUK p55 subfamily member 4 isoform 2

      See identical proteins and their annotated locations for NP_660125.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BC061694, BI737565
      Consensus CDS
      CCDS48271.1
      UniProtKB/Swiss-Prot
      Q0VG45, Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8
      UniProtKB/TrEMBL
      K3W4N9
      Related
      ENSMUSP00000077914.8, ENSMUST00000078874.14
      Conserved Domains (6) summary
      smart00569
      Location:47 → 81
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12034
      Location:245 → 305
      SH3_MPP4; Src Homology 3 domain of Membrane Protein, Palmitoylated 4 (or MAGUK p55 subfamily member 4)
      smart00072
      Location:435 → 618
      GuKc; Guanylate kinase homologues
      cd00992
      Location:152 → 231
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:427 → 617
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:89 → 135
      L27; L27 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      59160094..59202548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P7F1.1 GenPept UniProtKB/Swiss-Prot:Q6P7F1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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