Ifi35 interferon-induced protein 35 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifi35provided by MGI
Official Full Name: interferon-induced protein 35provided by MGI
Primary source: MGI:MGI:1917360
See related: Ensembl:ENSMUSG00000010358 AllianceGenome:MGI:1917360
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IFP35; ifi-35; 2010008K16Rik
Summary: Predicted to enable identical protein binding activity. Involved in positive regulation of inflammatory response; positive regulation of innate immune response; and positive regulation of non-canonical NF-kappaB signal transduction. Located in extracellular space. Is expressed in bladder. Orthologous to human IFI35 (interferon induced protein 35). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 43.0), duodenum adult (RPKM 34.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 65.07 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101339238..101349527)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (101448412..101458701)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFP35 aggravates Staphylococcus aureus infection by promoting Nrf2-regulated ferroptosis.
Title: IFP35 aggravates Staphylococcus aureus infection by promoting Nrf2-regulated ferroptosis.
The danger signal interferon-induced protein 35 (IFP35) mediates acetaminophen-induced liver injury.
Title: The danger signal interferon-induced protein 35 (IFP35) mediates acetaminophen-induced liver injury.
IFP35 family proteins promote neuroinflammation and multiple sclerosis.
Title: IFP35 family proteins promote neuroinflammation and multiple sclerosis.
High Expression of Ifi35 is associated with exacerbates lung inflammation and H5N1 influenza disease.
Title: Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimer.
Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-kappaB pathways.
Title: NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: interferon-induced 35 kDa protein homolog

Names: IFP 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027320.4 → NP_081596.1 interferon-induced 35 kDa protein homolog

See identical proteins and their annotated locations for NP_081596.1

Status: PROVISIONAL

Source sequence(s)

AL590996

Consensus CDS

CCDS25471.1

UniProtKB/Swiss-Prot

Q3V2E7, Q9D8C4

Related

ENSMUSP00000010502.7, ENSMUST00000010502.13

Conserved Domains (2) summary

pfam07292
Location:81 → 170

NID; Nmi/IFP 35 domain (NID)

pfam07334
Location:8 → 80

IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus