L1td1 LINE-1 type transposase domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: L1td1provided by MGI
Official Full Name: LINE-1 type transposase domain containing 1provided by MGI
Primary source: MGI:MGI:3578435
See related: Ensembl:ENSMUSG00000087166 AllianceGenome:MGI:3578435
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ECAT11
Summary: Predicted to enable single-stranded RNA binding activity. Predicted to be involved in retrotransposition. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of ribonucleoprotein complex. Is expressed in ovary and testis. Orthologous to human L1TD1 (LINE1 type transposase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward placenta adult (RPKM 10.8) See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 45.6 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (98614991..98626723)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (98726754..98738486)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of LINE-1 retrotransposition represses telomere reprogramming during mouse 2-cell embryo development.
Title: Inhibition of LINE-1 retrotransposition represses telomere reprogramming during mouse 2-cell embryo development.
Zidovudine inhibits telomere elongation, increases the transposable element LINE-1 copy number and compromises mouse embryo development.
Title: Zidovudine inhibits telomere elongation, increases the transposable element LINE-1 copy number and compromises mouse embryo development.
LINE-1 specific nuclear organization in mice olfactory sensory neurons.
Title: LINE-1 specific nuclear organization in mice olfactory sensory neurons.
LINE-1 overexpression triggers oxidative stress-induced DNA strand breaks and that an Engrailed adult function is to protect mesencephalic dopaminergic neurons through the repression of LINE-1 expression.
Title: Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression.
Here the authors show that TEX19.1, which is induced by developmentally programmed DNA hypomethylation, can directly interact with the LINE-1 (L1) retrotransposon-encoded protein L1-ORF1p, stimulate its polyubiquitylation and degradation, and restrict L1 mobilization.
Title: Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells.
These data demonstrate the dispensability of ECAT11/L1td1 in pluripotency, despite its specific expression.
Title: ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:234967 (e-PCR)
- UniSTS:234967

L1td1 (e-PCR), detects polymorphism
- UniSTS:532469

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in retrotransposition	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: LINE-1 type transposase domain-containing protein 1

Names: ES cell-associated protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.