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    Ptp4a1 protein tyrosine phosphatase 4a1 [ Mus musculus (house mouse) ]

    Gene ID: 19243, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ptp4a1provided by MGI
    Official Full Name
    protein tyrosine phosphatase 4a1provided by MGI
    Primary source
    MGI:MGI:1277096
    See related
    Ensembl:ENSMUSG00000026064 Ensembl:ENSMUSG00000117310 AllianceGenome:MGI:1277096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prl-1; C130021B01
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Involved in positive regulation of cell migration. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including bladder wall; incisor; nervous system; olfactory epithelium; and retina. Orthologous to human PTP4A1 (protein tyrosine phosphatase 4A1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 22.3), subcutaneous fat pad adult (RPKM 22.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptp4a1 in Genome Data Viewer
    Location:
    1 B; 1 11.47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (30979384..30988838, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (30940303..30949877, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2914 Neighboring gene PHD finger protein 3 Neighboring gene STARR-seq mESC enhancer starr_00509 Neighboring gene STARR-seq mESC enhancer starr_00510 Neighboring gene STARR-seq mESC enhancer starr_00512 Neighboring gene STARR-seq mESC enhancer starr_00514 Neighboring gene STARR-seq mESC enhancer starr_00515 Neighboring gene STARR-seq mESC enhancer starr_00516 Neighboring gene predicted gene, 53209 Neighboring gene STARR-seq mESC enhancer starr_00517 Neighboring gene Aly/REF export factor family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina. Yu L, et al. Biochim Biophys Acta, 2007 Sep. PMID 17673310, Free PMC Article
    2. Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration. Jiao Y, et al. Am J Physiol Gastrointest Liver Physiol, 2015 Jan 15. PMID 25377314, Free PMC Article
    3. PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth. Diamond RH, et al. Mol Cell Biol, 1994 Jun. PMID 8196618, Free PMC Article
    4. Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis. Bai Y, et al. Sci Rep, 2016 Sep 26. PMID 27666520, Free PMC Article
    5. Developmental expression of the murine Prl-1 protein tyrosine phosphatase gene. Rundle CH, et al. J Exp Zool, 1999 May 1. PMID 10194868

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-kappaB inactivation.
      Title: Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation.
    2. The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice.
      Title: The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice.
    3. data shed new light on the structural basis underlying the interaction between PRL phosphatases and CNNM transporters and provides a hypothesis about the molecular mechanism by which PRL-1, upon binding to CNNM2, might increase the intracellular concentration of Mg(2+) thereby contributing to tumor progression and metastasis.
      Title: Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
    4. Prl-1 is required for proper timing of liver regeneration after partial hepatectomy
      Title: Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration.
    5. PRL-1 binding to p115 RhoGAP provides a coordinated mechanism underlying ERK1/2 and RhoA activation
      Title: PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
    6. In cones and cone-derived cultured cells both Prl-1 activity and Prl-1 gene expression are modulated under oxidative stress.
      Title: Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25304, MGC102117

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein tyrosine phosphatase type IVA 1
    Names
    protein-tyrosine phosphatase of regenerating liver 1
    NP_001407715.1
    NP_001407716.1
    NP_001407717.1
    NP_001407718.1
    NP_001407719.1
    NP_001407720.1
    NP_035330.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420786.1 → NP_001407715.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153137
      UniProtKB/Swiss-Prot
      O09097, O09154, Q3UFU9, Q63739
      UniProtKB/TrEMBL
      B9EKL6

    2. NM_001420787.1 → NP_001407716.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153137
      UniProtKB/Swiss-Prot
      O09097, O09154, Q3UFU9, Q63739
      UniProtKB/TrEMBL
      B9EKL6

    3. NM_001420788.1 → NP_001407717.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153137
      UniProtKB/Swiss-Prot
      O09097, O09154, Q3UFU9, Q63739
      UniProtKB/TrEMBL
      B9EKL6
      Related
      ENSMUSP00000156862.2, ENSMUST00000232841.2

    4. NM_001420789.1 → NP_001407718.1  protein tyrosine phosphatase type IVA 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153137

    5. NM_001420790.1 → NP_001407719.1  protein tyrosine phosphatase type IVA 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153137

    6. NM_001420791.1 → NP_001407720.1  protein tyrosine phosphatase type IVA 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153137

    7. NM_011200.3 → NP_035330.1  protein tyrosine phosphatase type IVA 1 isoform 1

      See identical proteins and their annotated locations for NP_035330.1

      Status: VALIDATED

      Source sequence(s)
      AC153137
      Consensus CDS
      CCDS14858.1
      UniProtKB/Swiss-Prot
      O09097, O09154, Q3UFU9, Q63739
      UniProtKB/TrEMBL
      B9EKL6
      Related
      ENSMUSP00000027232.8, ENSMUST00000027232.15
      Conserved Domains (1) summary
      cd18537
      Location:1 → 167
      PTP-IVa1; protein tyrosine phosphatase type IVA 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      30979384..30988838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63739.1 GenPept UniProtKB/Swiss-Prot:Q63739

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