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    Man1a2 mannosidase, alpha, class 1A, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 17156, updated on 9-Dec-2024

    Summary

    Official Symbol
    Man1a2provided by MGI
    Official Full Name
    mannosidase, alpha, class 1A, member 2provided by MGI
    Primary source
    MGI:MGI:104676
    See related
    Ensembl:ENSMUSG00000008763 AllianceGenome:MGI:104676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PCR2; Man1b
    Summary
    Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Acts upstream of or within glycoprotein metabolic process; lung alveolus development; and respiratory gaseous exchange by respiratory system. Located in Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human MAN1A2 (mannosidase alpha class 1A member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 10.1), frontal lobe adult (RPKM 9.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Man1a2 in Genome Data Viewer
    Location:
    3 F2.2; 3 43.71 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100469519..100592789, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (100562203..100685473, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40106 Neighboring gene predicted gene 12474 Neighboring gene predicted gene, 54212 Neighboring gene STARR-seq mESC enhancer starr_08496 Neighboring gene STARR-positive B cell enhancer mm9_chr3:100372533-100372834 Neighboring gene STARR-positive B cell enhancer mm9_chr3:100490215-100490515 Neighboring gene STARR-seq mESC enhancer starr_08498 Neighboring gene STARR-positive B cell enhancer ABC_E3455 Neighboring gene predicted gene 43464 Neighboring gene STARR-seq mESC enhancer starr_08501 Neighboring gene predicted gene, 40107

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in Golgi membrane  
    located_in Golgi membrane PubMed 
    is_active_in endoplasmic reticulum  

    General protein information

    Preferred Names
    mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
    Names
    alpha-1,2-mannosidase IB
    mannosidase 1, beta
    processing alpha-1,2-mannosidase IB
    NP_034893.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010763.2NP_034893.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

      See identical proteins and their annotated locations for NP_034893.1

      Status: VALIDATED

      Source sequence(s)
      AK013515, AK041117, AK078047, AK078291, AK153336, BC068192, CB723579
      Consensus CDS
      CCDS17676.1
      UniProtKB/Swiss-Prot
      P39098, Q5SUY6, Q5SUY7, Q60599, Q9CUY9
      Related
      ENSMUSP00000008907.8, ENSMUST00000008907.14
      Conserved Domains (2) summary
      pfam01532
      Location:187626
      Glyco_hydro_47; Glycosyl hydrolase family 47
      cl26511
      Location:109208
      Neuromodulin_N; Gap junction protein N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      100469519..100592789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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