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    Ccdc174 coiled-coil domain containing 174 [ Mus musculus (house mouse) ]

    Gene ID: 232236, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ccdc174provided by MGI
    Official Full Name
    coiled-coil domain containing 174provided by MGI
    Primary source
    MGI:MGI:2444652
    See related
    Ensembl:ENSMUSG00000034083 AllianceGenome:MGI:2444652
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C130022K22Rik
    Summary
    Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human CCDC174 (coiled-coil domain containing 174). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.0), CNS E14 (RPKM 4.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc174 in Genome Data Viewer
    Location:
    6 D1; 6 40.9 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (91819983..91876830)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (91843154..91899849)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:91629122-91629420 Neighboring gene predicted gene, 40387 Neighboring gene predicted gene, 30628 Neighboring gene STARR-seq mESC enhancer starr_16652 Neighboring gene solute carrier family 6 (neurotransmitter transporter, taurine), member 6 Neighboring gene STARR-seq mESC enhancer starr_16656 Neighboring gene STARR-seq mESC enhancer starr_16660 Neighboring gene glutamate receptor interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E6456 Neighboring gene RIKEN cDNA 4930590J08 gene Neighboring gene predicted gene, 53299

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Transgenic (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 174

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172730.2 → NP_766318.2  coiled-coil domain-containing protein 174

      See identical proteins and their annotated locations for NP_766318.2

      Status: VALIDATED

      Source sequence(s)
      AC168852, AK039818, BC051147, BY624970
      Consensus CDS
      CCDS20370.2
      UniProtKB/Swiss-Prot
      Q3U155, Q80XC8, Q8CA20
      UniProtKB/TrEMBL
      A0A0R4J0L8
      Related
      ENSMUSP00000049280.6, ENSMUST00000037783.7
      Conserved Domains (2) summary
      PTZ00121
      Location:3 → 329
      PTZ00121; MAEBL; Provisional
      pfam13300
      Location:230 → 303
      DUF4078; Domain of unknown function (DUF4078)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      91819983..91876830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255347.2 → XP_030111207.1  coiled-coil domain-containing protein 174 isoform X1

      UniProtKB/Swiss-Prot
      Q3U155, Q80XC8, Q8CA20
      UniProtKB/TrEMBL
      A0A0R4J0L8
      Conserved Domains (2) summary
      PTZ00121
      Location:3 → 329
      PTZ00121; MAEBL; Provisional
      pfam13300
      Location:230 → 303
      DUF4078; Domain of unknown function (DUF4078)

    2. XM_036166055.1 → XP_036021948.1  coiled-coil domain-containing protein 174 isoform X1

      UniProtKB/Swiss-Prot
      Q3U155, Q80XC8, Q8CA20
      UniProtKB/TrEMBL
      A0A0R4J0L8
      Conserved Domains (2) summary
      PTZ00121
      Location:3 → 329
      PTZ00121; MAEBL; Provisional
      pfam13300
      Location:230 → 303
      DUF4078; Domain of unknown function (DUF4078)

    3. XM_036166056.1 → XP_036021949.1  coiled-coil domain-containing protein 174 isoform X2

      UniProtKB/Swiss-Prot
      Q3U155, Q80XC8, Q8CA20
      Conserved Domains (2) summary
      PTZ00121
      Location:3 → 328
      PTZ00121; MAEBL; Provisional
      pfam13300
      Location:230 → 303
      DUF4078; Domain of unknown function (DUF4078)

    4. XM_030255348.2 → XP_030111208.1  coiled-coil domain-containing protein 174 isoform X3

      UniProtKB/TrEMBL
      Q8C4Q1
      Conserved Domains (1) summary
      pfam13300
      Location:122 → 195
      DUF4078; Domain of unknown function (DUF4078)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U155.1 GenPept UniProtKB/Swiss-Prot:Q3U155

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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