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    Vwa3a von Willebrand factor A domain containing 3A [ Mus musculus (house mouse) ]

    Gene ID: 233813, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Vwa3aprovided by MGI
    Official Full Name
    von Willebrand factor A domain containing 3Aprovided by MGI
    Primary source
    MGI:MGI:3041229
    See related
    Ensembl:ENSMUSG00000030889 AllianceGenome:MGI:3041229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E030013G06Rik
    Summary
    Is expressed in 4th ventricle; choroid plexus; and lateral ventricle choroid plexus. Orthologous to human VWA3A (von Willebrand factor A domain containing 3A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 12.2), lung adult (RPKM 1.7) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vwa3a in Genome Data Viewer
    Location:
    7 F2; 7 64.9 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120336554..120404769)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120737331..120805546)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ubiquinol cytochrome c reductase core protein 2 Neighboring gene PDZ domain containing 9 Neighboring gene modulator of smoothened Neighboring gene predicted gene, 57518 Neighboring gene short chain dehydrogenase/reductase family 42E, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E6592 Neighboring gene nuclear encoded tRNA leucine 1 (anticodon TAG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor A domain-containing protein 3A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177697.3 → NP_808365.2  von Willebrand factor A domain-containing protein 3A

      See identical proteins and their annotated locations for NP_808365.2

      Status: VALIDATED

      Source sequence(s)
      AC099930, AC122214
      Consensus CDS
      CCDS40112.1
      UniProtKB/Swiss-Prot
      Q3UVV9, Q8C349
      Related
      ENSMUSP00000033180.7, ENSMUST00000033180.13
      Conserved Domains (1) summary
      cl00057
      Location:142 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      120336554..120404769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241753.3 → XP_011240055.1  von Willebrand factor A domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_011240055.1

      Conserved Domains (1) summary
      cl00057
      Location:142 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. XM_030242509.1 → XP_030098369.1  von Willebrand factor A domain-containing protein 3A isoform X1

      Conserved Domains (1) summary
      cl00057
      Location:142 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. XM_030242510.2 → XP_030098370.1  von Willebrand factor A domain-containing protein 3A isoform X2

      UniProtKB/Swiss-Prot
      Q3UVV9, Q8C349
      Related
      ENSMUSP00000129136.2, ENSMUST00000166668.9
      Conserved Domains (1) summary
      cl00057
      Location:142 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    4. XM_030242511.2 → XP_030098371.1  von Willebrand factor A domain-containing protein 3A isoform X2

      UniProtKB/Swiss-Prot
      Q3UVV9, Q8C349
      Related
      ENSMUSP00000133029.2, ENSMUST00000167213.9
      Conserved Domains (1) summary
      cl00057
      Location:142 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    5. XM_030242512.2 → XP_030098372.1  von Willebrand factor A domain-containing protein 3A isoform X2

      UniProtKB/Swiss-Prot
      Q3UVV9, Q8C349
      Conserved Domains (1) summary
      cl00057
      Location:142 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    6. XM_011241752.4 → XP_011240054.1  von Willebrand factor A domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_011240054.1

      Conserved Domains (1) summary
      cl00057
      Location:142 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    7. XM_006507690.5 → XP_006507753.1  von Willebrand factor A domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_006507753.1

      Conserved Domains (1) summary
      cl00057
      Location:142 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    8. XM_011241754.2 → XP_011240056.1  von Willebrand factor A domain-containing protein 3A isoform X3

      Conserved Domains (1) summary
      cl00057
      Location:74 → 229
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    9. XM_030242513.1 → XP_030098373.1  von Willebrand factor A domain-containing protein 3A isoform X4

      Conserved Domains (1) summary
      cl00057
      Location:580 → 733
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RNA

    1. XR_378236.5 RNA Sequence

      Related
      ENSMUST00000168600.9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UVV9.1 GenPept UniProtKB/Swiss-Prot:Q3UVV9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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