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    Spats2 spermatogenesis associated, serine-rich 2 [ Mus musculus (house mouse) ]

    Gene ID: 72572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spats2provided by MGI
    Official Full Name
    spermatogenesis associated, serine-rich 2provided by MGI
    Primary source
    MGI:MGI:1919822
    See related
    Ensembl:ENSMUSG00000051934 AllianceGenome:MGI:1919822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p59; 59kDa; Scr59; p59scr; 2700012F11Rik
    Summary
    Located in cytoplasm. Orthologous to human SPATS2 (spermatogenesis associated serine rich 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 21.6), placenta adult (RPKM 20.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spats2 in Genome Data Viewer
    Location:
    15 F1; 15 56.01 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99023783..99111096)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99125926..99213215)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene complement component 1, q subcomponent-like 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member C22 Neighboring gene predicted gene, 57817 Neighboring gene predicted gene, 25183 Neighboring gene STARR-seq mESC enhancer starr_39699 Neighboring gene predicted gene, 46538 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 3 Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99082061-99082244 Neighboring gene STARR-positive B cell enhancer ABC_E1486 Neighboring gene microspherule protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel protein p59(scr), which is expressed at specific stages of mouse spermatogenesis. Senoo M, et al. Biochem Biophys Res Commun, 2002 Apr 12. PMID 11944913
    2. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article
    3. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    spermatogenesis-associated serine-rich protein 2
    Names
    serine-rich spermatocytes and round spermatid 59 kDa protein
    serine-rich spermatocytes and round spermatid protein, 59kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418664.1 → NP_001405593.1  spermatogenesis-associated serine-rich protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157610, AC161198
      UniProtKB/Swiss-Prot
      Q3UX77, Q8C810, Q8K1N4, Q8R1P6

    2. NM_001418665.1 → NP_001405594.1  spermatogenesis-associated serine-rich protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157610, AC161198
      UniProtKB/Swiss-Prot
      Q3UX77, Q8C810, Q8K1N4, Q8R1P6

    3. NM_001418666.1 → NP_001405595.1  spermatogenesis-associated serine-rich protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157610, AC161198

    4. NM_001418667.1 → NP_001405596.1  spermatogenesis-associated serine-rich protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157610, AC161198

    5. NM_001418668.1 → NP_001405597.1  spermatogenesis-associated serine-rich protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157610, AC161198

    6. NM_001418669.1 → NP_001405598.1  spermatogenesis-associated serine-rich protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157610, AC161198

    7. NM_001418670.1 → NP_001405599.1  spermatogenesis-associated serine-rich protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157610, AC161198

    8. NM_139140.2 → NP_631879.1  spermatogenesis-associated serine-rich protein 2 isoform 1

      See identical proteins and their annotated locations for NP_631879.1

      Status: VALIDATED

      Source sequence(s)
      AC157610, AC161198
      Consensus CDS
      CCDS27816.1
      UniProtKB/Swiss-Prot
      Q3UX77, Q8C810, Q8K1N4, Q8R1P6
      Related
      ENSMUSP00000070549.5, ENSMUST00000063517.6
      Conserved Domains (1) summary
      pfam07139
      Location:81 → 385
      DUF1387; Protein of unknown function (DUF1387)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99023783..99111096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245737.1 → XP_011244039.1  spermatogenesis-associated serine-rich protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011244039.1

      UniProtKB/Swiss-Prot
      Q3UX77, Q8C810, Q8K1N4, Q8R1P6
      Conserved Domains (1) summary
      pfam07139
      Location:81 → 385
      DUF1387; Protein of unknown function (DUF1387)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1N4.1 GenPept UniProtKB/Swiss-Prot:Q8K1N4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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