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    Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 18710, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pik3r3provided by MGI
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 3provided by MGI
    Primary source
    MGI:MGI:109277
    See related
    Ensembl:ENSMUSG00000028698 Ensembl:ENSMUSG00000111410 AllianceGenome:MGI:109277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p55; p55pik
    Summary
    Enables 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within insulin receptor signaling pathway. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 19.3), CNS E14 (RPKM 19.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pik3r3 in Genome Data Viewer
    Location:
    4 D1; 4 53.1 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116078593..116160253)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116221400..116303056)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:115849369-115849478 Neighboring gene Pik3r3 upstream reading frame Neighboring gene STARR-seq mESC enhancer starr_11134 Neighboring gene STARR-seq mESC enhancer starr_11135 Neighboring gene LLP homolog, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E838 Neighboring gene STARR-seq mESC enhancer starr_11136 Neighboring gene BRCA1 associated RING domain 1 pseudogene Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene STARR-seq mESC enhancer starr_11138 Neighboring gene predicted gene, 52760 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116180277-116180386 Neighboring gene IAP promoted placental gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-κB pathway. Wang G, et al. Angiogenesis, 2013 Jul. PMID 23354733
    2. p55γ degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning. Li Z, et al. Cardiovasc Res, 2023 Nov 15. PMID 37527538
    3. Role of the p55-gamma subunit of PI3K in ALK-induced cell migration: RNAi-based selection of cell migration regulators. Seo M, et al. Cell Adh Migr, 2017 May 4. PMID 27322022, Free PMC Article
    4. VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas. Lee H, et al. J Clin Invest, 2024 Apr 15. PMID 38618953, Free PMC Article
    5. PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis. Yang X, et al. Exp Mol Med, 2018 Jan 19. PMID 29350678, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas.
      Title: VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas.
    2. p55gamma degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning.
      Title: p55γ degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning.
    3. PIK3R3 regulates the expression of PPAR-alpha.The activation of PIK3R3 decreased hepatosteatosis.The novel PIK3R3-HNF4alpha-PPAR-alpha signaling axis plays a significant role in hepatic lipid metabolism.
      Title: PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis.
    4. These data support an important role for the p55gamma subunit of PI3K in ALK-induced cell migration during brain development
      Title: Role of the p55-gamma subunit of PI3K in ALK-induced cell migration: RNAi-based selection of cell migration regulators.
    5. p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-kappaB pathway.
      Title: p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-κB pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-3-kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-3-kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit gamma
    Names
    PI3-kinase regulatory subunit gamma
    PI3-kinase subunit p55-gamma
    PI3K regulatory subunit gamma
    phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
    phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
    ptdIns-3-kinase regulatory subunit gamma
    ptdIns-3-kinase regulatory subunit p55-gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355584.2 → NP_001342513.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670603
      Consensus CDS
      CCDS18509.1
      UniProtKB/Swiss-Prot
      Q64143
      UniProtKB/TrEMBL
      Q3TST3, Q3UXE9
      Conserved Domains (3) summary
      cd09930
      Location:351 → 454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59 → 167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172 → 332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_001355585.2 → NP_001342514.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670603
      Consensus CDS
      CCDS18509.1
      UniProtKB/Swiss-Prot
      Q64143
      UniProtKB/TrEMBL
      Q3TST3, Q3UXE9
      Conserved Domains (3) summary
      cd09930
      Location:351 → 454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59 → 167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172 → 332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    3. NM_001355586.2 → NP_001342515.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670603
      UniProtKB/TrEMBL
      Q3TST3
      Conserved Domains (3) summary
      cd09930
      Location:307 → 410
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:15 → 123
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:128 → 288
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    4. NM_001421303.1 → NP_001408232.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL670603
      UniProtKB/TrEMBL
      Q3TST3

    5. NM_001421304.1 → NP_001408233.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL670603
      UniProtKB/TrEMBL
      Q3TST3

    6. NM_001421305.1 → NP_001408234.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL670603

    7. NM_001421306.2 → NP_001408235.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670603
      UniProtKB/TrEMBL
      Q3TST3
      Related
      ENSMUSP00000150163.2, ENSMUST00000216692.2

    8. NM_001429908.1 → NP_001416837.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL670603

    9. NM_001429909.1 → NP_001416838.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL670603
      UniProtKB/TrEMBL
      Q3TST3

    10. NM_001429910.1 → NP_001416839.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL670603
      UniProtKB/TrEMBL
      Q3TST3

    11. NM_181585.7 → NP_853616.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_853616.1

      Status: VALIDATED

      Source sequence(s)
      AL670603
      Consensus CDS
      CCDS18509.1
      UniProtKB/Swiss-Prot
      Q64143
      UniProtKB/TrEMBL
      Q3TST3, Q3UXE9
      Related
      ENSMUSP00000030464.8, ENSMUST00000030464.14
      Conserved Domains (3) summary
      cd09930
      Location:351 → 454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59 → 167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172 → 332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116078593..116160253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502860.5 → XP_006502923.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

      See identical proteins and their annotated locations for XP_006502923.1

      UniProtKB/TrEMBL
      Q3TST3
      Conserved Domains (3) summary
      cd09942
      Location:59 → 167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172 → 332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
      cl15255
      Location:351 → 396
      SH2; Src homology 2 (SH2) domain

    2. XM_006502859.4 → XP_006502922.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

      See identical proteins and their annotated locations for XP_006502922.1

      UniProtKB/TrEMBL
      Q3TST3
      Conserved Domains (3) summary
      cd09942
      Location:59 → 167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172 → 332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
      cl15255
      Location:351 → 396
      SH2; Src homology 2 (SH2) domain

    3. XM_030253316.2 → XP_030109176.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2

      Conserved Domains (3) summary
      cd09942
      Location:15 → 123
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:128 → 288
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
      cl15255
      Location:307 → 352
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64143.1 GenPept UniProtKB/Swiss-Prot:Q64143

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