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    Eef1d eukaryotic translation elongation factor 1 delta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eef1dprovided by RGD
    Official Full Name
    eukaryotic translation elongation factor 1 deltaprovided by RGD
    Primary source
    RGD:621174
    See related
    EnsemblRapid:ENSRNOG00000021638 AllianceGenome:RGD:621174
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; guanyl-nucleotide exchange factor activity; and heat shock protein binding activity. Predicted to be involved in several processes, including cellular response to heat; cellular response to ionizing radiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in endoplasmic reticulum; fibrillar center; and nucleoplasm. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol and glutamatergic synapse. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 250.4), Muscle (RPKM 240.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eef1d in Genome Data Viewer
    Location:
    7q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109462645..109478021, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107581930..107596735, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116928264..116942981, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 6 Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene GDP-L-fucose synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Oncogenic potential of mouse translation elongation factor-1 delta, a novel cadmium-responsive proto-oncogene. Joseph P, et al. J Biol Chem, 2002 Feb 22. PMID 11711542
    2. Elongation factor 1 delta is enhanced following exposure to ionizing radiation. Jung M, et al. Cancer Res, 1994 May 15. PMID 8168075
    3. Quantitative analysis of synaptic phosphorylation and protein expression. Trinidad JC, et al. Mol Cell Proteomics, 2008 Apr. PMID 18056256
    4. Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. Sanders J, et al. J Cell Sci, 1996 May. PMID 8743958
    5. Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing. Kaitsuka T, et al. EMBO Rep, 2011 Jul 1. PMID 21597468, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation elongation factor 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor 1-delta
    Names
    EF-1-delta
    guanine nucleotide exchange protein
    translation elongation factor 1-delta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013104.1 → NP_001013122.1  elongation factor 1-delta

      See identical proteins and their annotated locations for NP_001013122.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079391
      UniProtKB/TrEMBL
      A0A8L2QI22
      Conserved Domains (1) summary
      pfam00736
      Location:567 → 650
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      109462645..109478021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263305.1 → XP_063119375.1  elongation factor 1-delta isoform X13

      UniProtKB/TrEMBL
      A0A8I6GFR4

    2. XM_063263302.1 → XP_063119372.1  elongation factor 1-delta isoform X13

      UniProtKB/TrEMBL
      A0A8I6GFR4

    3. XM_063263296.1 → XP_063119366.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      A0A8L2QI22

    4. XM_063263303.1 → XP_063119373.1  elongation factor 1-delta isoform X13

      UniProtKB/TrEMBL
      A0A8I6GFR4

    5. XM_063263300.1 → XP_063119370.1  elongation factor 1-delta isoform X13

      UniProtKB/TrEMBL
      A0A8I6GFR4

    6. XM_017594765.3 → XP_017450254.1  elongation factor 1-delta isoform X14

      UniProtKB/TrEMBL
      A0A8I6GFR4, A0A8I6GJH3

    7. XM_039078815.2 → XP_038934743.1  elongation factor 1-delta isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZUU1, A0A8I6GFR4, A6HS30
      Related
      ENSRNOP00000081329.1, ENSRNOT00000111979.2
      Conserved Domains (1) summary
      pfam00736
      Location:193 → 276
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    8. XM_008765561.3 → XP_008763783.1  elongation factor 1-delta isoform X17

      See identical proteins and their annotated locations for XP_008763783.1

      UniProtKB/TrEMBL
      A0A8I6AQM3, A0A8I6GFR4, A6HS29
      Conserved Domains (1) summary
      pfam00736
      Location:174 → 257
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    9. XM_008765557.3 → XP_008763779.1  elongation factor 1-delta isoform X15

      See identical proteins and their annotated locations for XP_008763779.1

      UniProtKB/Swiss-Prot
      Q68FR9
      UniProtKB/TrEMBL
      A0A8I6GFR4, A6HS33
      Conserved Domains (1) summary
      pfam00736
      Location:198 → 281
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    10. XM_008765559.3 → XP_008763781.1  elongation factor 1-delta isoform X15

      See identical proteins and their annotated locations for XP_008763781.1

      UniProtKB/Swiss-Prot
      Q68FR9
      UniProtKB/TrEMBL
      A0A8I6GFR4, A6HS33
      Conserved Domains (1) summary
      pfam00736
      Location:198 → 281
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    11. XM_039078811.2 → XP_038934739.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      A0A8L2QI22
      Conserved Domains (1) summary
      pfam00736
      Location:568 → 651
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    12. XM_063263301.1 → XP_063119371.1  elongation factor 1-delta isoform X13

      UniProtKB/TrEMBL
      A0A8I6GFR4

    13. XM_008765551.4 → XP_008763773.1  elongation factor 1-delta isoform X7

      See identical proteins and their annotated locations for XP_008763773.1

      UniProtKB/TrEMBL
      A0A8I5ZWY7, A0A8L2QI22
      Conserved Domains (1) summary
      pfam00736
      Location:587 → 670
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    14. XM_063263283.1 → XP_063119353.1  elongation factor 1-delta isoform X2

      UniProtKB/TrEMBL
      A0A8L2QI22

    15. XM_063263288.1 → XP_063119358.1  elongation factor 1-delta isoform X5

      UniProtKB/TrEMBL
      A0A8L2QI22

    16. XM_063263282.1 → XP_063119352.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      A0A8L2QI22

    17. XM_063263290.1 → XP_063119360.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      A0A8L2QI22

    18. XM_017594767.3 → XP_017450256.1  elongation factor 1-delta isoform X14

      UniProtKB/TrEMBL
      A0A8I6GFR4, A0A8I6GJH3

    19. XM_063263287.1 → XP_063119357.1  elongation factor 1-delta isoform X4

      UniProtKB/TrEMBL
      A0A8L2QI22

    20. XM_063263285.1 → XP_063119355.1  elongation factor 1-delta isoform X3

      UniProtKB/TrEMBL
      A0A8L2QI22

    21. XM_039078818.2 → XP_038934746.1  elongation factor 1-delta isoform X17

      UniProtKB/TrEMBL
      A0A8I6AQM3, A0A8I6GFR4, A6HS29
      Conserved Domains (1) summary
      pfam00736
      Location:174 → 257
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    22. XM_039078813.2 → XP_038934741.1  elongation factor 1-delta isoform X11

      UniProtKB/TrEMBL
      A0A8L2QI22
      Conserved Domains (1) summary
      pfam00736
      Location:563 → 646
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    23. XM_039078814.2 → XP_038934742.1  elongation factor 1-delta isoform X12

      UniProtKB/TrEMBL
      A0A8L2QI22
      Related
      ENSRNOP00000096307.2, ENSRNOT00000110570.2
      Conserved Domains (1) summary
      pfam00736
      Location:544 → 627
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    24. XM_039078812.2 → XP_038934740.1  elongation factor 1-delta isoform X10

      UniProtKB/TrEMBL
      A0A8L2QI22
      Conserved Domains (1) summary
      pfam00736
      Location:567 → 650
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    25. XM_063263298.1 → XP_063119368.1  elongation factor 1-delta isoform X10

      UniProtKB/TrEMBL
      A0A8L2QI22

    26. XM_063263293.1 → XP_063119363.1  elongation factor 1-delta isoform X8

      UniProtKB/TrEMBL
      A0A8L2QI22

    27. XM_063263294.1 → XP_063119364.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      A0A8L2QI22
      Related
      ENSRNOP00000087171.2, ENSRNOT00000098616.2

    28. XM_063263286.1 → XP_063119356.1  elongation factor 1-delta isoform X3

      UniProtKB/TrEMBL
      A0A8L2QI22

    29. XM_063263291.1 → XP_063119361.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZWY7, A0A8L2QI22
      Related
      ENSRNOP00000092090.2, ENSRNOT00000106771.2

    30. XM_063263281.1 → XP_063119351.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      A0A8L2QI22

    31. XM_063263295.1 → XP_063119365.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      A0A8L2QI22

    32. XM_063263299.1 → XP_063119369.1  elongation factor 1-delta isoform X10

      UniProtKB/TrEMBL
      A0A8L2QI22

    33. XM_063263284.1 → XP_063119354.1  elongation factor 1-delta isoform X2

      UniProtKB/TrEMBL
      A0A8L2QI22

    34. XM_063263292.1 → XP_063119362.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZWY7, A0A8L2QI22

    35. XM_063263280.1 → XP_063119350.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      A0A8L2QI22
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FR9.2 GenPept UniProtKB/Swiss-Prot:Q68FR9

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