SCG3 secretogranin III [Homo sapiens (human)] - Gene

Summary

Official Symbol: SCG3provided by HGNC
Official Full Name: secretogranin IIIprovided by HGNC
Primary source: HGNC:HGNC:13707
See related: Ensembl:ENSG00000104112 MIM:611796; AllianceGenome:HGNC:13707
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SGIII
Summary: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Expression: Biased expression in brain (RPKM 94.6), adrenal (RPKM 8.5) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 15q21.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (51681503..51721026)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (49488960..49528517)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (51973700..52013223)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SCG3 Protein Expression in Glioma Associates With less Malignancy and Favorable Clinical Outcomes.
Title: SCG3 Protein Expression in Glioma Associates With less Malignancy and Favorable Clinical Outcomes.
Concurrent Physiological and Pathological Angiogenesis in Retinopathy of Prematurity and Emerging Therapies.
Title: Concurrent Physiological and Pathological Angiogenesis in Retinopathy of Prematurity and Emerging Therapies.
SCG3 may be involved in PQinduced astrocyte activation via regulation of the expression and selective recruitment of cellular factors, thus suggesting that SCG3 may represent an indicator of astrocyte activation.
Title: Secretogranin III may be an indicator of paraquat-induced astrocyte activation and affects the recruitment of BDNF during this process.
This review summarizes our current knowledge of Scg3 as a regulatory protein of secretory granules, highlights its new role as a highly disease-selective angiogenic factor, and envisions Scg3 inhibitors as "selective angiogenesis blockers" for targeted therapy of diabetic retinopathy. [review]
Title: Secretogranin III: a diabetic retinopathy-selective angiogenic factor.
results suggested an association between the fucosylated glycoform of short-form SgIII and Small Cell Lung Carcinoma
Title: Glycobiomarker, Fucosylated Short-Form Secretogranin III Levels Are Increased in Serum of Patients with Small Cell Lung Carcinoma.
HBXIP facilitates the proliferation of hepatoma cells by up-regulating SCG3 via E2F1 and miR-509-3p modulation.
Title: The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells.
SCG3 is essential in the process and targeting of neuropeptides and neurotrophins, its participation in the pathological progression of Alzheimer's disease may be suggested
Title: Secretory sorting receptors carboxypeptidase E and secretogranin III in amyloid β-associated neural degeneration in Alzheimer's disease.
SCG3 may be involved in apoptosis signal transduction as a caspase substrate.It may be a pivotal component of the neuroendocrine pathway & play an important role in neuronal communication & neurotransmitter release.
Title: Dysregulated expression of secretogranin III is involved in neurotoxin-induced dopaminergic neuron apoptosis.
Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome.
Title: Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population.
This short review deals with investigations in neuroendocrine tumors (NETs) with antibodies against defined epitopes of chromogranins (Cgs) A and B and secretogranins (Sgs) II and III.
Title: Immunohistochemical and biochemical studies with region-specific antibodies to chromogranins A and B and secretogranins II and III in neuroendocrine tumors.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH67999 (e-PCR)
- UniSTS:4195

SHGC-36808 (e-PCR)
- UniSTS:17032

SHGC-3227 (e-PCR)
- UniSTS:26001

SCG3_1974 (e-PCR)
- UniSTS:280982

RH26968 (e-PCR)
- UniSTS:88236

D15S1017 (e-PCR), detects polymorphism
- UniSTS:64209

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein localization to secretory granule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in secretory granule lumen	TAS Traceable Author Statement more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: secretogranin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013214.1 RefSeqGene

Range

5151..44674

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001165257.2 → NP_001158729.1 secretogranin-3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks the alternate exon containing the translation intiation site compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AF453583, AK296466, BI552493

Consensus CDS

CCDS53947.1

UniProtKB/Swiss-Prot

Q8WXD2

Related

ENSP00000445205.2, ENST00000542355.6

Conserved Domains (1) summary

pfam15467
Location:1 → 236

SGIII; Secretogranin-3
NM_013243.4 → NP_037375.2 secretogranin-3 isoform 1 precursor

See identical proteins and their annotated locations for NP_037375.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF453583

Consensus CDS

CCDS10142.1

UniProtKB/Swiss-Prot

A8K2B0, B3KQP6, B4DK99, F5H3R8, Q8WXD2, Q96C83, Q96GE8, Q9Y6G7

Related

ENSP00000220478.3, ENST00000220478.8

Conserved Domains (1) summary

pfam15467
Location:17 → 468

SGIII; Secretogranin-3