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    Car8 carbonic anhydrase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297814, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Car8provided by RGD
    Official Full Name
    carbonic anhydrase 8provided by RGD
    Primary source
    RGD:1304709
    See related
    EnsemblRapid:ENSRNOG00000005669 AllianceGenome:RGD:1304709
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ca8
    Summary
    Predicted to enable carbonate dehydratase activity and zinc ion binding activity. Predicted to act upstream of or within positive regulation of calcium-mediated signaling. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 3. Orthologous to human CA8 (carbonic anhydrase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 539.8), Lung (RPKM 299.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Car8 in Genome Data Viewer
    Location:
    5q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (26102767..26199819, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (21302940..21402395, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (21249018..21345810, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene eukaryotic translation initiation factor 1, pseudogene 8 Neighboring gene uncharacterized LOC134478931 Neighboring gene ribosomal protein S16, pseudogene 4 Neighboring gene uncharacterized LOC108350928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1. Hirota J, et al. Biochem J, 2003 Jun 1. PMID 12611586, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105764

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase-related protein
    Names
    CA-VIII
    CARP
    carbonic anhydrase VIII
    NP_001009662.1
    XP_038965331.1
    XP_038965332.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009662.1 → NP_001009662.1  carbonic anhydrase-related protein

      See identical proteins and their annotated locations for NP_001009662.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087586
      UniProtKB/Swiss-Prot
      Q5PPN4
      UniProtKB/TrEMBL
      A6JFP9
      Related
      ENSRNOP00000007802.5, ENSRNOT00000007802.9
      Conserved Domains (1) summary
      cd03120
      Location:35 → 289
      alpha_CARP_VIII; Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      26102767..26199819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109404.2 → XP_038965332.1  carbonic anhydrase-related protein isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7B9, A0A8I5Y6A0
      Related
      ENSRNOP00000074141.3, ENSRNOT00000081296.3
      Conserved Domains (1) summary
      cl00012
      Location:20 → 170
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    2. XM_039109403.2 → XP_038965331.1  carbonic anhydrase-related protein isoform X1

      Conserved Domains (1) summary
      cl00012
      Location:35 → 175
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PPN4.3 GenPept UniProtKB/Swiss-Prot:Q5PPN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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