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    Scyl3 SCY1 like pseudokinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360866, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Scyl3provided by RGD
    Official Full Name
    SCY1 like pseudokinase 3provided by RGD
    Primary source
    RGD:1308992
    See related
    EnsemblRapid:ENSRNOG00000025318 AllianceGenome:RGD:1308992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308992
    Summary
    Predicted to enable identical protein binding activity. Predicted to act upstream of or within inflammatory response; neuron differentiation; and protein localization. Predicted to be located in several cellular components, including Golgi membrane; endoplasmic reticulum; and lamellipodium. Orthologous to human SCYL3 (SCY1 like pseudokinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 94.6), Spleen (RPKM 70.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Scyl3 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (78811595..78836202)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (76278428..76303038)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (82230938..82255640)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 2 Neighboring gene kinesin-associated protein 3 Neighboring gene uncharacterized LOC120096301 Neighboring gene FIGNL1 interacting regulator of recombination and mitosis Neighboring gene uncharacterized LOC102555981 Neighboring gene methyltransferase 18, RPL3 N3(tau)-histidine Neighboring gene peptidylprolyl isomerase D, pseudogene 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. Sullivan A, et al. Exp Cell Res, 2003 Apr 1. PMID 12651155
    2. Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability. Kuliyev E, et al. J Neurosci, 2018 Mar 7. PMID 29437892, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spinal cord motor neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein-associating with the carboxyl-terminal domain of ezrin
    Names
    SCY1-like 3
    SCY1-like, kinase-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191828.2 → NP_001178757.1  protein-associating with the carboxyl-terminal domain of ezrin isoform 1

      See identical proteins and their annotated locations for NP_001178757.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IDC6, D3ZK09
      Conserved Domains (3) summary
      pfam00069
      Location:26 → 245
      Pkinase; Protein kinase domain
      sd00044
      Location:256 → 283
      HEAT; HEAT repeat [structural motif]
      cl21453
      Location:9 → 247
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001429727.1 → NP_001416656.1  protein-associating with the carboxyl-terminal domain of ezrin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    3. NM_001429728.1 → NP_001416657.1  protein-associating with the carboxyl-terminal domain of ezrin isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RNA

    1. NR_190778.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      78811595..78836202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769661.4 → XP_008767883.2  protein-associating with the carboxyl-terminal domain of ezrin isoform X2

      Related
      ENSRNOP00000003461.5, ENSRNOT00000003551.8

    2. XM_063272491.1 → XP_063128561.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X1

      UniProtKB/TrEMBL
      A6IDC6, D3ZK09

    3. XM_006250176.5 → XP_006250238.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X3

      See identical proteins and their annotated locations for XP_006250238.1

      Conserved Domains (2) summary
      sd00044
      Location:119 → 146
      HEAT; HEAT repeat [structural motif]
      cl21453
      Location:22 → 110
      PKc_like; Protein Kinases, catalytic domain

    4. XM_039090910.2 → XP_038946838.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X4

      Conserved Domains (2) summary
      sd00044
      Location:114 → 141
      HEAT; HEAT repeat [structural motif]
      cl21453
      Location:1 → 105
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_005492254.2 RNA Sequence

    2. XR_005492255.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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