Anks1b ankyrin repeat and sterile alpha motif domain containing 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Anks1bprovided by RGD
Official Full Name: ankyrin repeat and sterile alpha motif domain containing 1Bprovided by RGD
Primary source: RGD:1565556
See related: EnsemblRapid:ENSRNOG00000024870 AllianceGenome:RGD:1565556
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EB-1; AIDA-1; RGD1565556
Summary: Predicted to enable ephrin receptor binding activity. Involved in postsynapse to nucleus signaling pathway. Acts upstream of or within receptor localization to synapse. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; postsynaptic density, intracellular component; and presynaptic cytosol. Orthologous to human ANKS1B (ankyrin repeat and sterile alpha motif domain containing 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 313.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (26200649..27366552)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (24313339..25479307)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (30507135..31684604)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CaMKII-mediated redistribution of AIDA-1 is similar to that observed for SynGAP. CaMKII-mediated removal of two abundant PSD-95-binding proteins from the PSD core during activity is expected to initiate a molecular reorganization at the PSD.
Title: CaMKII-mediated displacement of AIDA-1 out of the postsynaptic density core.
localization as well as the activity-induced redistribution of AIDA-1 at the postsynaptic density, was examined.
Title: AIDA-1 Moves out of the Postsynaptic Density Core under Excitatory Conditions.
It impairs hippocampallong-term potentiation.
Title: PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition.
data suggest that AIDA-1 serves as a direct signaling link between synapses and the nucleus in adult rat brain.
Title: Organization of amyloid-beta protein precursor intracellular domain-associated protein-1 in the rat brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF403875 (e-PCR)
- UniSTS:246528

D7Rat47 (e-PCR)
- UniSTS:119045

BF401678 (e-PCR)
- UniSTS:245516

RH144500 (e-PCR)
- UniSTS:233745

RH144012 (e-PCR)
- UniSTS:233258

RH138629 (e-PCR)
- UniSTS:220716

D7Rat194 (e-PCR), detects polymorphism
- UniSTS:228142

D7Got16 (e-PCR)
- UniSTS:114773

BF387391 (e-PCR)
- UniSTS:244329

RH136686 (e-PCR)
- UniSTS:218775

RH144380 (e-PCR)
- UniSTS:233625

BE102988 (e-PCR)
- UniSTS:244418

BE102489 (e-PCR)
- UniSTS:244200

BF387129 (e-PCR)
- UniSTS:244211

AW533069 (e-PCR)
- UniSTS:261875

BE097681 (e-PCR)
- UniSTS:244726

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission, postsynaptic	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynapse to nucleus signaling pathway	EXP Inferred from Experiment more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within receptor localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity by receptor localization to synapse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ankyrin repeat and sterile alpha motif domain-containing protein 1B

Names: E2A-PBX1-associated protein; amyloid-beta protein intracellular domain-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271371.3 → NP_001258300.2 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P0C6S7

Conserved Domains (6) summary

PHA02874
Location:7 → 386

PHA02874; ankyrin repeat protein; Provisional

cd09499
Location:807 → 873

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:878 → 942

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:1042 → 1191

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:58 → 89

ANK; ANK repeat [structural motif]

pfam12796
Location:63 → 158

Ank_2; Ankyrin repeats (3 copies)
NM_001414940.1 → NP_001401869.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6GAL6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

26200649..27366552

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079051.2 → XP_038934979.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X13

Conserved Domains (4) summary

PHA02874
Location:7 → 386

PHA02874; ankyrin repeat protein; Provisional

sd00045
Location:58 → 89

ANK; ANK repeat [structural motif]

pfam12796
Location:63 → 158

Ank_2; Ankyrin repeats (3 copies)

cl15755
Location:807 → 840

SAM_superfamily; SAM (Sterile alpha motif )
XM_063263442.1 → XP_063119512.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X11
XM_039079050.2 → XP_038934978.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X12

UniProtKB/Swiss-Prot

P0C6S7

Conserved Domains (5) summary

cd09499
Location:759 → 825

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:830 → 894

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:934 → 1083

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:58 → 89

ANK; ANK repeat [structural motif]

pfam12796
Location:63 → 158

Ank_2; Ankyrin repeats (3 copies)
XM_017594833.3 → XP_017450322.2 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X7

UniProtKB/Swiss-Prot

P0C6S7

Conserved Domains (6) summary

PHA02874
Location:7 → 386

PHA02874; ankyrin repeat protein; Provisional

cd09499
Location:807 → 873

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:878 → 942

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:1067 → 1216

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:58 → 89

ANK; ANK repeat [structural motif]

pfam12796
Location:63 → 158

Ank_2; Ankyrin repeats (3 copies)
XM_008765241.4 → XP_008763463.3 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X10

UniProtKB/Swiss-Prot

P0C6S7

Related

ENSRNOP00000056036.6, ENSRNOT00000059269.7

Conserved Domains (6) summary

PHA02874
Location:7 → 386

PHA02874; ankyrin repeat protein; Provisional

cd09499
Location:807 → 873

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:878 → 942

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:982 → 1131

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:58 → 89

ANK; ANK repeat [structural motif]

pfam12796
Location:63 → 158

Ank_2; Ankyrin repeats (3 copies)
XM_017594832.3 → XP_017450321.2 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X5

UniProtKB/Swiss-Prot

P0C6S7

Related

ENSRNOP00000078170.2, ENSRNOT00000114777.2

Conserved Domains (6) summary

PHA02874
Location:7 → 386

PHA02874; ankyrin repeat protein; Provisional

cd09499
Location:807 → 873

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:878 → 942

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:1067 → 1216

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:58 → 89

ANK; ANK repeat [structural motif]

pfam12796
Location:63 → 158

Ank_2; Ankyrin repeats (3 copies)
XM_017594830.3 → XP_017450319.2 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X2

UniProtKB/Swiss-Prot

P0C6S7

Conserved Domains (6) summary

PHA02874
Location:7 → 386

PHA02874; ankyrin repeat protein; Provisional

cd09499
Location:807 → 873

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:878 → 942

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:1067 → 1216

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:58 → 89

ANK; ANK repeat [structural motif]

pfam12796
Location:63 → 158

Ank_2; Ankyrin repeats (3 copies)
XM_063263441.1 → XP_063119511.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X8
XM_039079046.2 → XP_038934974.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X3

UniProtKB/Swiss-Prot

P0C6S7

Conserved Domains (6) summary

PHA02874
Location:7 → 386

PHA02874; ankyrin repeat protein; Provisional

cd09499
Location:807 → 873

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:878 → 942

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:1066 → 1215

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:58 → 89

ANK; ANK repeat [structural motif]

pfam12796
Location:63 → 158

Ank_2; Ankyrin repeats (3 copies)
XM_039079047.2 → XP_038934975.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X6

UniProtKB/Swiss-Prot

P0C6S7

Conserved Domains (6) summary

PHA02874
Location:7 → 386

PHA02874; ankyrin repeat protein; Provisional

cd09499
Location:807 → 873

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:878 → 942

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:1042 → 1191

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:58 → 89

ANK; ANK repeat [structural motif]

pfam12796
Location:63 → 158

Ank_2; Ankyrin repeats (3 copies)
XM_039079048.2 → XP_038934976.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X9

UniProtKB/Swiss-Prot

P0C6S7

Related

ENSRNOP00000108068.1, ENSRNOT00000150575.1

Conserved Domains (6) summary

PHA02874
Location:7 → 386

PHA02874; ankyrin repeat protein; Provisional

cd09499
Location:807 → 873

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:878 → 942

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:982 → 1131

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:58 → 89

ANK; ANK repeat [structural motif]

pfam12796
Location:63 → 158

Ank_2; Ankyrin repeats (3 copies)
XM_017594828.3 → XP_017450317.2 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X1

UniProtKB/Swiss-Prot

P0C6S7

Related

ENSRNOP00000084534.2, ENSRNOT00000102313.2

Conserved Domains (6) summary

PHA02874
Location:7 → 386

PHA02874; ankyrin repeat protein; Provisional

cd09499
Location:807 → 873

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:878 → 942

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:1067 → 1216

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:58 → 89

ANK; ANK repeat [structural motif]

pfam12796
Location:63 → 158

Ank_2; Ankyrin repeats (3 copies)
XM_063263440.1 → XP_063119510.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X4
XM_063263443.1 → XP_063119513.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X14