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    Sh3d21 SH3 domain containing 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362598, updated on 9-Dec-2024

    Summary

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    Symbol
    Sh3d21provided by RGD
    Full Name
    SH3 domain containing 21provided by RGD
    Primary source
    RGD:1305090
    See related
    EnsemblRapid:ENSRNOG00000024566 AllianceGenome:RGD:1305090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305090
    Summary
    Predicted to be involved in actin filament organization and cell migration. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human SH3D21 (SH3 domain containing 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 246.7), Lung (RPKM 43.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh3d21 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (143713718..143729073, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (138429180..138444540, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144161881..144178161, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 40 Neighboring gene uncharacterized LOC108351032 Neighboring gene eva-1 homolog B Neighboring gene thyroid hormone receptor associated protein 3 Neighboring gene uncharacterized LOC120103176

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing protein 21
    Names
    SH3 domain-containing kinase-binding protein 1-like
    SH3 domain-containing protein C1orf113 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162535.1 → NP_001156007.1  SH3 domain-containing protein 21

      Status: VALIDATED

      Source sequence(s)
      AW528754, BC162054
      UniProtKB/TrEMBL
      B1WC96, F6PUS4
      Conserved Domains (1) summary
      cd12142
      Location:70 → 123
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      143713718..143729073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764049.4 → XP_008762271.1  SH3 domain-containing protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJ24
      Related
      ENSRNOP00000092858.2, ENSRNOT00000106147.2
      Conserved Domains (3) summary
      cd11874
      Location:156 → 208
      SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
      cd12142
      Location:255 → 308
      SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
      cl17036
      Location:72 → 125
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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