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    MRS2 Mrs2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854511, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MRS2
    Official Full Name
    Mrs2p
    Primary source
    SGD:S000005861
    Locus tag
    YOR334W
    See related
    AllianceGenome:SGD:S000005861; FungiDB:YOR334W; VEuPathDB:YOR334W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cardiolipin binding activity and magnesium ion transmembrane transporter activity. Involved in mitochondrial magnesium ion transmembrane transport. Located in mitochondrion. Is active in mitochondrial inner membrane. Used to study Barth syndrome. Orthologous to human MRS2 (magnesium transporter MRS2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MRS2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (944596..946008)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA-directed DNA polymerase gamma MIP1 Neighboring gene H(+)-transporting V1 sector ATPase subunit E Neighboring gene alanine--tRNA ligase Neighboring gene Kre5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cardiolipin deficiency leads to the destabilization of mitochondrial magnesium channel MRS2 in Barth syndrome. Joshi A, et al. Hum Mol Genet, 2023 Dec 1. PMID 37721533
    2. The G-M-N motif determines ion selectivity in the yeast magnesium channel Mrs2p. Sponder G, et al. Metallomics, 2013 Jun. PMID 23686104
    3. Structural and functional characterization of the N-terminal domain of the yeast Mg2+ channel Mrs2. Khan MB, et al. Acta Crystallogr D Biol Crystallogr, 2013 Sep. PMID 23999289
    4. Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of Mrs2, a magnesium ion transporter from yeast inner mitochondrial membrane. Khan MB, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Jun 1. PMID 20516593, Free PMC Article
    5. Molecular mechanism of Mg2+-dependent gating in CorA. Dalmas O, et al. Nat Commun, 2014 Apr 2. PMID 24694723, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A functional and structural analysis of the regulatory domain of the eukaryotic divalent magnesium 2+ channel Mrs2 from yeast inner mitochondrial membrane is presented.
      Title: Structural and functional characterization of the N-terminal domain of the yeast Mg2+ channel Mrs2.
    2. inner mitochondrial domain of the Mrs2 from Saccharomyces cerevisae was overexpressed, purified and crystallized in two different crystal forms. The crystals diffracted X-rays to 1.83 and 4.16 A resolution, respectively.
      Title: Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of Mrs2, a magnesium ion transporter from yeast inner mitochondrial membrane.
    3. The Mrs2p is of central significance for the transport of Mg(2+) into mitochondria of S. cerevisiae.
      Title: Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel.
    4. Data presented support the notion that effects of mutations in Mrs2p on group II intron splicing are a consequence of changes in steady-state mitochondrial Mg2+ concentrations.
      Title: Mutational analysis of functional domains in Mrs2p, the mitochondrial Mg2+ channel protein of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cardiolipin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial magnesium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial magnesium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial magnesium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mrs2p
    NP_014979.1
    • Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      944596..946008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183754.1 → NP_014979.1  TPA: Mrs2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W329, Q01926
      UniProtKB/TrEMBL
      A6ZPG4, B3LJZ3, C7GNT2, C8ZH86, N1NX14
      Conserved Domains (1) summary
      cd12823
      Location:66 → 374
      Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01926.2

    Gene LinkOut

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