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    Yy1 YY1 transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24919, updated on 4-Jan-2025

    Summary

    Official Symbol
    Yy1provided by RGD
    Official Full Name
    YY1 transcription factorprovided by RGD
    Primary source
    RGD:3982
    See related
    EnsemblRapid:ENSRNOG00000004339 AllianceGenome:RGD:3982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NMP1; NF-E1; NMP-1; UCRBP
    Summary
    Enables sequence-specific DNA binding activity. Involved in several processes, including cellular response to interleukin-1; negative regulation of cell growth involved in cardiac muscle cell development; and regulation of transcription by RNA polymerase II. Located in nuclear matrix. Part of transcription regulator complex. Used to study type 1 diabetes mellitus. Biomarker of type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 145.7), Kidney (RPKM 115.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Yy1 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (133471615..133500875)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (127706739..127736499)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (132702443..132726848)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351299 Neighboring gene uncharacterized LOC120103621 Neighboring gene S-phase kinase-associated protein 1 pseudogene Neighboring gene solute carrier family 25 member 29 Neighboring gene uncharacterized LOC134479257 Neighboring gene microRNA 345

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables RNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables SMAD binding  
    enables chromatin binding  
    enables cis-regulatory region sequence-specific DNA binding  
    enables four-way junction DNA binding  
    enables protein binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding  
    Items 1 - 25 of 39
    Process Evidence Code Pubs
    involved_in B cell differentiation  
    involved_in DNA damage response  
    acts_upstream_of_or_within RNA localization  
    acts_upstream_of_or_within anterior/posterior pattern specification  
    acts_upstream_of_or_within camera-type eye morphogenesis  
    involved_in cellular response to UV  
    involved_in cellular response to interleukin-1 PubMed 
    involved_in chromatin remodeling  
    involved_in chromosome organization  
    involved_in double-strand break repair via homologous recombination  
    acts_upstream_of_or_within_positive_effect gene expression  
    involved_in hemopoiesis  
    involved_in immunoglobulin heavy chain V-D-J recombination  
    involved_in negative regulation of cell growth involved in cardiac muscle cell development PubMed 
    involved_in negative regulation of gene expression  
    involved_in negative regulation of interferon-beta production  
    involved_in negative regulation of miRNA transcription  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of DNA repair  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of gene expression  
    involved_in positive regulation of telomere maintenance in response to DNA damage  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of DNA repair  
    involved_in regulation of DNA replication  
    involved_in regulation of DNA strand elongation  
    involved_in regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    involved_in regulation of cell cycle  
    involved_in regulation of chromosome organization  
    involved_in regulation of embryonic development  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to UV-C  
    involved_in response to prostaglandin F PubMed 
    involved_in spermatogenesis  
    involved_in telomere maintenance  
    Items 1 - 25 of 39
    Component Evidence Code Pubs
    part_of Ino80 complex  
    part_of PcG protein complex  
    part_of PcG protein complex  
    located_in chromatin  
    located_in chromatin  
    part_of chromatin silencing complex  
    located_in nuclear matrix PubMed 
    located_in nucleus  
    part_of transcription regulator complex  
    part_of transcription regulator complex PubMed 
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    transcriptional repressor protein YY1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173290.2NP_775412.1  transcriptional repressor protein YY1

      See identical proteins and their annotated locations for NP_775412.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A7Q7, Q8CHJ4
      Related
      ENSRNOP00000005743.2, ENSRNOT00000005743.5
      Conserved Domains (2) summary
      COG5048
      Location:265404
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:324344
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      133471615..133500875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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