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    Pnpla7 patatin-like phospholipase domain containing 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246246, updated on 27-Nov-2024

    Summary

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    Symbol
    Pnpla7provided by RGD
    Full Name
    patatin-like phospholipase domain containing 7provided by RGD
    Primary source
    RGD:708466
    See related
    EnsemblRapid:ENSRNOG00000008190 AllianceGenome:RGD:708466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ntel; Ntel1; Nte-related
    Summary
    Predicted to enable lysophospholipase activity. Predicted to be involved in phosphatidylcholine catabolic process. Predicted to be located in endoplasmic reticulum membrane and lipid droplet. Predicted to be active in endoplasmic reticulum. Orthologous to human PNPLA7 (patatin like phospholipase domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 258.8), Thymus (RPKM 158.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pnpla7 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28180670..28259673)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (7782572..7861504)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2182191..2261890)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene diphthamide biosynthesis 7 Neighboring gene mitochondrial ribosomal protein L41 Neighboring gene glutathione S-transferase pi 1, pseudogene 3 Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor Neighboring gene ectonucleoside triphosphate diphosphohydrolase 8 Neighboring gene NADPH oxidase activator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat NTE-related esterase is a membrane-associated protein, hydrolyzes phenyl valerate, and interacts with diisopropylfluorophosphate through a serine catalytic machinery. Xie M, et al. Arch Biochem Biophys, 2003 Aug 15. PMID 12893290
    2. Identification of two novel splicing variants of murine NTE-related esterase. Chang PA, et al. Gene, 2012 Apr 15. PMID 22326266
    3. The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain. Heier C, et al. J Biol Chem, 2017 Nov 17. PMID 28887301, Free PMC Article
    4. Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase. Kienesberger PC, et al. J Biol Chem, 2008 Feb 29. PMID 18086666
    5. Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. Winrow CJ, et al. Nat Genet, 2003 Apr. PMID 12640454

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108975

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lysophospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysophospholipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    patatin-like phospholipase domain-containing protein 7
    Names
    NTE-related esterase
    liver NTE-related protein 1
    neuropathy target esterase like 1
    patatin-like phospholipase domain-containing protein 7-like
    NP_653339.2
    XP_038960180.1
    XP_038960181.1
    XP_038960182.1
    XP_038960183.1
    XP_038960184.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144738.2 → NP_653339.2  patatin-like phospholipase domain-containing protein 7

      See identical proteins and their annotated locations for NP_653339.2

      Status: VALIDATED

      Source sequence(s)
      BC083547, BC091230, DN934725
      UniProtKB/Swiss-Prot
      Q5BK26, Q5XIX2, Q8K3H9
      UniProtKB/TrEMBL
      A6JT00, G3V745
      Related
      ENSRNOP00000011633.5, ENSRNOT00000011633.7
      Conserved Domains (4) summary
      cd07225
      Location:930 → 1235
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      COG0664
      Location:164 → 306
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      COG1752
      Location:935 → 1221
      RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
      cd00038
      Location:601 → 709
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28180670..28259673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104252.2 → XP_038960180.1  patatin-like phospholipase domain-containing protein 7 isoform X1

      Related
      ENSRNOP00000112741.1, ENSRNOT00000141487.1
      Conserved Domains (2) summary
      cd00038
      Location:601 → 709
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl11396
      Location:930 → 955
      Patatin_and_cPLA2; Patatins and Phospholipases

    2. XM_039104253.2 → XP_038960181.1  patatin-like phospholipase domain-containing protein 7 isoform X2

      Conserved Domains (1) summary
      cd00038
      Location:601 → 709
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    3. XM_039104254.2 → XP_038960182.1  patatin-like phospholipase domain-containing protein 7 isoform X3

      Conserved Domains (1) summary
      cd00038
      Location:601 → 709
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    4. XM_039104255.2 → XP_038960183.1  patatin-like phospholipase domain-containing protein 7 isoform X4

      Conserved Domains (2) summary
      cd07225
      Location:349 → 654
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      cd00038
      Location:20 → 128
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    5. XM_039104256.2 → XP_038960184.1  patatin-like phospholipase domain-containing protein 7 isoform X5

      Conserved Domains (1) summary
      cd07225
      Location:263 → 568
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

    RNA

    1. XR_005501774.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK26.2 GenPept UniProtKB/Swiss-Prot:Q5BK26

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